Maybe you’re always begging for bathroom breaks on car trips. Maybe you wake up to tinkle twice every night. Maybe you’re just worried about the sheer amount of pee that flows from your body. Should you be concerned?  Not likely, according to the experts. Yes, too frequent urination, in combination with other symptoms, can be a sign of a medical problem. But there’s such a wide variance of acceptable urination levels, chances are you fall well within the norm.  The average human pees six or seven times per day, but Dr. Sven Wenske, a urologist with the Columbia University Medical Center, is wary of telling people these numbers. It’s more important, he says, to make sure your pee sensation feels healthy than to count the number of times you go.  1. You control more about your pee than you think. Pee “is dependent on fluid intake,” Wenske told HuffPost. A person who consumes five liters of water per day, for example, may have to pee 10 times, while someone who drinks less will only have to go three or four times. (Humans are generally advised to drink between 2.7 and 3.7 liters per day, though you can also gauge the level you need by your pee color. More on that later.) The type of liquid you drink factors in, too: Coffee can irritate your bladder, Wenske says, making you have to pee more than if you were just drinking water. And older people have smaller bladders, which explains why grandma always has to pull over during road trips….

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Publication date: 1 November 2018Source: Colloids and Surfaces B: Biointerfaces, Volume 171Author(s): Cristina Lorente, Laura Cabeza, Beatriz Clares, Raúl Ortiz, Lyda Halbaut, Ángel V. Delgado, Gloria Perazzoli, José Prados, José L. Arias, Consolación MelguizoAbstractMagnetoliposomes (MLPs) offer many new possibilities in cancer therapy and diagnosis, including the transport of antitumor drugs, hyperthermia treatment, detection using imaging techniques, and even cell migration. However, high biocompatibility and functionality after cell internalization are essential to their successful ap…

Publication date: November 2018Source: Phytochemistry, Volume 155Author(s): Qinghao Jin, Jin Woo Lee, Hari Jang, Hye Lim Lee, Jun Gu Kim, Wanying Wu, Dongho Lee, Eun-Hee Kim, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon HwangAbstractAn undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3ʹ …

Source: PhytochemistryCategory: Chemistry Source Type: research

Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP03860K, PaperYang Zhou, Muzammal Hussain, Guanglin Kuang, Jiancun Zhang, Yaoquan Tu ATAD2 has emerged as a promising bromodomain (BRD)-containing therapeutic drug target in multiple human cancers. However, recent druggability assessment studies predicted ATAD2 ’s BRD as a target ‘difficult to drug’ because… The content of this RSS Feed (c) The Royal Society of Chemistry

WARNING: GRAPHIC CONTENT Alexa Juckiewicz-Caspell, 10, from Clacton-on-Sea, Essex, developed Steven Johnson Syndrome after taking medication to relieve her pain condition.

[Govt of the Gambia] State House, Banjul, 7th August 2018 – The First Lady of the Republic, Her Excellency Fatoumatta Bah-Barrow has said the Gambia is making a steady progress in the fight against breast and cervical cancers, despite the high infection rates being registered across the sub region.

The objective of this research was therefore to evaluate the potential use of ultrasound technology in combination with temperature (50°-80 °C) with the purpose of releasing Cd from brown crab (Cancer pagurus), thereby reducing the Cd content in its meat. Female crabs were immersed in a water bath at 50, 65, and 80 °C in presence or absence of ultrasound; Cd concentration in the water was monitored along time. At the end of the process, Cd content in brown and white crab meat was likewise quantified. Treatment temperature did not bear an influence on the release of Cd in absence of ultrasound, but proved to…

Source: Ultrasonics SonochemistryCategory: Chemistry Authors: Tags: Ultrason Sonochem Source Type: research

ConclusionsThere are currently several instruments validated in Spanish to assess pain in individuals with advanced dementia and communication problems (Abbey, Algoplus, Doloplus y PAINAD-Sp). However, these instruments have still not been widely used in research, and their psychometric properties could be improved.ResumenAntecedentes y objetivoLa valoración del dolor en personas con demencia avanzada y problemas de comunicación continúa siendo infradiagnosticada e infratratada debido a la dificultad que conlleva realizar esta valoración. Esta revisión pretende explorar y sintetizar c&oac…

ConclusionSNM offers a good and durable solution for some functional bladder problems, if patients are well selected. There may also be additional extra-urinary benefits that contribute to improvements in QoL. SNM was well tolerated by our patients with an encouraging response rate, especially in psychologically stable patients with idiopathic dysfunctions.

CONCLUSIONS: SGLT2i are usually safe and provide multiple benefits for patients with T2DM. However, during particular medical circumstances, and in association with usual co-medications, particularly if baseline glomerular filtration rate is decreased, patients treated with SGLT2i may be at risk of AKI, thus warranting caution when prescribed.
PMID: 30084579 [PubMed – in process]

CONCLUSIONS: Our findings suggest that H. pylori infection may be a risk factor for all-cause mortality among CRC patients who are evaluated by PET/CT. Multicenter studies with larger patient groups are needed to confirm our findings.
PMID: 30084577 [PubMed – in process]

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