Title: Agent Orange Linked to Bladder Cancer, Thyroid Problems, Panel SaysCategory: Health NewsCreated: 3/10/2016 12:00:00 AMLast Editorial Review: 3/11/2016 12:00:00 AM

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(University of Alabama at Birmingham) Doxorubicin is a chemotherapy drug used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Researchers have found an important contributor to that heart pathology — disruption of the metabolism that controls immune responses in the spleen and heart. This dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation leads to advanced heart failure.

ne G. van Breda

Nitrate levels in our water resources have increased in many areas of the world largely due to applications of inorganic fertilizer and animal manure in agricultural areas. The regulatory limit for nitrate in public drinking water supplies was set to protect against infant methemoglobinemia, but other health effects were not considered. Risk of specific cancers and birth defects may be increased when nitrate is ingested under conditions that increase formation of N-nitroso compounds. We previously reviewed epidemiologic studies before 2005 of nitrate intake from drinking water and cancer, adverse reprod…

In conclusion, Elk1 inhibition induced thyroid cancer cell apoptosis and restrained their proliferation by regulating Egr‑1/PTEN, indicating a potential role for Elk1 in thyroid cancer treatment.
PMID: 30015900 [PubMed – as supplied by publisher]

Source: Oncology ReportsCategory: Cancer & Oncology Tags: Oncol Rep Source Type: research

New York health officials are investigating after significant rates of leukemia, bladder, lung and thyroid cancers were found in three Long Island counties – 16 percent of all cases in New York state.

PIN2/TERF1 interacting telomerase inhibitor 1 (PINX1) is a telomerase inhibitor located on human chromosome 8p23, and also act as a tumor suppressor in several types of cancers, including breast, gastric, ovarian and bladder cancer; However, the role of PINX1 expression in papillary thyroid carcinoma (PTC) has not been defined. Therefore, we investigated the role of PINX1 expression in PTC by analyzing the correlation between PINX1 expression and various clinicopathological factors. Immunohistochemistry for PINX1 was performed using a tissue microarray of samples taken from the 160 patients with PTC.

Source: Human PathologyCategory: Pathology Authors: Tags: Original Contributions Source Type: research

AW, Horenblas S, Gietema JA, van Leeuwen FE, Schaapveld M
Purpose Testicular cancer (TC) treatment increases risk of subsequent malignant neoplasms (SMNs). It is unknown whether changes in TC treatment over time have affected SMN risk. Methods Solid SMN risk was evaluated in a multicenter cohort comprising 5,848 1-year survivors treated for TC before age 50 years between 1976 and 2007. SMN incidence was compared with cancer incidence in the general population. Treatment-specific risks were assessed using multivariable regression in a case-cohort design. Results After a median follow-up of 14.1 years, 350…

Source: Clinical Lung CancerCategory: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research

Conclusion: This study provided latest evidence on epidemiology of cancer in the southeast of
Iran that could be used to empower prevention and control interventions in a developing country.
PMID: 29936728 [PubMed – in process]

CONCLUSION: First Nations people in Canada have disproportionately high rates of certain cancers, providing evidence to support public health policy and programming. More research is needed to identify factors contributing to the significantly lower incidence observed for various cancer types. Novel methods for studying disparities in cancer incidence among First Nations people are required to support ongoing cancer control planning and advocacy.
PMID: 29981110 [PubMed – as supplied by publisher]

Source: Canadian Journal of Public HealthCategory: International Medicine & Public Health Authors: Tags: Can J Public Health Source Type: research

The tumor necrosis factor (TNF)- α- induced protein 8 (TNFAIP8/TIPE) family is a death effector domain (DED)-containing protein family with four identified members: TNFAIP8 (TIPE), TNFAIP8L1 (TIPE1), TNFAIP8L2 (TIPE2), and TNFAIP8L3 (TIPE3). These proteins were found to play crucial roles in the regulation of immune homeostasis, i nflammation, and cancer development. Intensive research in the past two decades revealed a strong correlation of TIPE proteins with development of various cancers including cancers of the bladder, blood, bone, breast, cervix, colon, esophagus, endometrium, stomach, liver, lung, ovary, pancr…

Source: Cancer LettersCategory: Cancer & Oncology Authors: Tags: Mini-review Source Type: research

Conclusions: We continue to collect additional cases and follow up data; however, our initial analysis shows that 18F-FDG PET/CT detected new, unexpected FDG-avid additional primary malignancies in at least 3% of VA cancer patients, which is 2.5 times higher than what was previously reported in the non-VA cancer patients. Therefore, in cancer cases with unexpected FDG PET/CT findings, further clarification with closer follow up, other imaging modalities or pathological confirmation may be more critical in VA versus non-VA patients.

Source: Journal of Nuclear MedicineCategory: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research

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