A species of bacteria linked to ventilator-associated pneumonia, Acinetobacter baumannii, can persist on examination gloves and transfer to plastic surfaces commonly found in hospitals. Medscape Medical News

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AbstractIn the present investigation, five novel Cr(VI) reducing bacteria were isolated from tannery effluents and solid wastes and identified asKosakonia cowanii MKPF2,Klebsiella pneumonia MKPF5,Acinetobacter gerneri MKPF7,Klebsiella variicola MKPF8 andSerratia marcescens MKPF12 by 16S rDNA gene sequence analysis. The maximum tolerance concentration of Cr(VI) as K2Cr2O7 of the bacterial isolates was varying up to 2000  mg/L. Among the investigated bacterial isolates,A. gerneri MKPF7 was best in terms of reduction rate. The optimum temperatures for growth and Cr(VI) reduction by the bacterial isolates were 35 and 40 &…

Multidrug-resistant (MDR) strains of both Acinetobacter baumannii (AB) and Pseudomonas aeruginosa (PA) as causative ventilator-associated pneumonia (VAP) pathogens are becoming increasingly common. Still, the risk factors associated with this increased resistance have yet to be elucidated. The purpose of this study was to examine the changing sensitivity patterns of these pathogens over time and determine which risk factors predict MDR in trauma patients with VAP.
Patients with either AB or PA VAP over 10 years were stratified by pathogen sensitivity (sensitive [SEN] and MDR), age, severity of shock…

CONCLUSION: From this study, it can be concluded that ceftriaxone + sulbactam + EDTA alone or in combination with colistin can be an effective empiric treatment of various MDR nosocomial infections and can serve as an effective alternative to carbapenems.

Source: Indian Journal of CancerCategory: Cancer & Oncology Authors: Source Type: research

Background: Ventilator-associated pneumonia (VAP) is a complication with high morbidity and mortality, especially if multiresistant (MR) microorganisms (MO) like Pseudomonas aeruginosa (Pae), Klebsiella pneumoniae (Kpn) and Acinetobacter spp (Ac) are involved. Therefore, it is of interest to highlight the prevalence and resistance of MO found in tracheal aspirates (TA) of intensive care (IC) patients, in order to establish appropriate empirical therapy (ET).

Source: International Journal of Infectious DiseasesCategory: Infectious Diseases Authors: Tags: UMP. 059 Source Type: research

Background: Acinetobacter baumannii is an opportunistic nosocomial pathogen responsible for 2 –10% of all gram-negative nosocomial infections and is classified in the six most important multidrug-resistant microorganisms in hospitals worldwide. Most frequent and lethal (35-52%) infections include ventilator associated pneumonia and bacteremia. Outbreaks of resistant strains are increasingl y reported worldwide, being sustained by similar clusters that successfully spread due to acquisition of antimicrobial resistance genes.

Source: International Journal of Infectious DiseasesCategory: Infectious Diseases Authors: Tags: UMP. 044 Source Type: research

In conclusion, aging increased susceptibility to A. baumannii infection and impaired efficacies of antibiotics and vaccine. The aged mice model of A. baumannii pneumonia is a suitable model to study the effects of aging on A. baumannii infection and assess the efficacies of antibiotics and vaccines against A. baumannii for the elderly.
PMID: 30018181 [PubMed – as supplied by publisher]

Source: AgingCategory: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research

Conclusion: This study reveals that the prevalence of MDR Gram-negative pathogens is perceived to be on the rise. Prescription patterns indicate high levels of variability. Hence, antibiotic stewardship is essential to standardize antibiotic prescriptions not only for efficacy but also to reduce the burden of multiple drug resistance.

Authors: Tang X, Xiao M, Zhuo C, Xu Y, Zhong N
Background: With the different situation for clinical antibiotic usage and its management in different regions and medical institutions, the antimicrobial resistance varied in different level. However, the epidemiological data of multi-drug resistant (MDR) strains from the department of respiration is limited. Thus, this study aims to investigate the epidemiology of bacteria isolated from inpatients of respiratory departments, and analyze the distribution variation of major multi-drug resistant bacteria in China.
Methods: Based on data from China Antimicro…

Conclusions: The main finding of our study was that increased bacterial cytotoxicity might be a risk factor for short-term mortality in ICU patients with A. baumannii VAP.
PMID: 29997922 [PubMed]

ConclusionMultiplex-PCR permits simultaneous detection of several bacterial pathogens in a single reaction with best turnaround time that permit optimization of emergency diagnosis of VAP and subsequently improve early management of selective bacterial pathogens.

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