BOWEL cancer symptoms can include stomach pain, a change in bowel habits, and finding blood in your stool. But, blood in your poo could also be a sign of haemorrhoids – this is how to tell the difference.

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After an eight-week trial, and three days deliberating, the jury found Monsanto’s product did cause Johnson’s cancer, and the company ‘acted with malice and fraud and should be punished’.

A California jury on Friday found Monsanto liable in a lawsuit filed by a man who alleged the company’s glyphosate-based weed-killers, including Roundup, caused his cancer and ordered the company to pay $289 million in damages.

Source: Reuters: HealthCategory: Consumer Health News Tags: healthNews Source Type: news

Authors: Furusawa Y, Yamada S, Itai S, Nakamura T, Fukui M, Harada H, Kaneko MK, Kato Y
Rat podoplanin (rPDPN) is a recognized lymphatic endothelial cell marker and is expressed on the podocytes of kidney and type I lung alveolar cells. rPDPN is a type I transmembrane sialoglycoprotein and induces platelet aggregation via the C-type lectin-like receptor-2 of platelets. It comprises four platelet aggregation-stimulating (PLAG) domains: PLAG1-3, present in the N-terminus, and PLAG4, in the center of the PDPN protein. Previously, we developed a mouse anti-rPDPN monoclonal antibody clone, PMab-2, by immunizing…

Publication date: Available online 10 August 2018Source: Biochimica et Biophysica Acta (BBA) – Molecular Basis of DiseaseAuthor(s): Hui Emma Zhang, James M. Henderson, Mark D. GorrellAbstractHepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xe…

CONCLUSIONS Both Gail model and Tyrer-Cuzick models can be used to evaluate breast cancer risk. The Gail model has relatively lower accuracy in evaluating breast cancer risk in Jiangxi province of China and the Tyrer-Cuzick model had relatively higher accuracy.
PMID: 30089770 [PubMed – in process]

Authors: Zhu L, Gangadaran P, Kalimuthu S, Oh JM, Baek SH, Jeong SY, Lee SW, Lee J, Ahn BC
Exosomes are endogenous nanocarriers that can deliver biological information between cells. They are secreted by all cell types, including immune cells such as natural killer (NK) cells. However, mammalian cells release low quantities of exosomes, and the purification of exosomes is difficult. Here, nanovesicles were developed by extrusion of NK cells through filters with progressively smaller pore sizes to obtain exosome mimetics (NK-EM). The anti-tumour effect of the NK-EM was confirmed in vitro and in vivo. The mo…

Publication date: 1 September 2018Source: Life Sciences, Volume 208Author(s): Nurul Hannim Zaidun, Zar Chi Thent, Azian Abd LatiffAbstractThe incidence of diseases related to oxidative stress disorders have been increased dramatically. Alternatives medicine or the active compound extracted from the natural products received great attention among researches at the present era. Naringenin (NG), a common dietary flavanone, found in the citrus fruits such as oranges, bergamots, lemons and grapefruit. It is used in the several oxidative stress disorders as the nutraceutical value of the compound emerges. Functionally, the antio…

Source: Life SciencesCategory: Biology Source Type: research

Publication date: Available online 10 August 2018Source: Life SciencesAuthor(s): Yu Huang, Lie Liu, Aiguo LiuAbstractDickkopf-1(DKK-1) has been identified as a secretory protein that can inhibit the Wnt signaling transduction pathway. It is well known that the Wnt signaling pathway plays an important role in embryogenesis, organogenesis and homeostasis. This signaling cascade is essential for many normal physiological processes such as cellular proliferation, tissue regeneration, embryonic development and many other systemic and local effects, and it can be regulated at different levels. Therefore, defects in the pathway m…

Source: Life SciencesCategory: Biology Source Type: research

Publication date: Available online 10 August 2018Source: Carbohydrate PolymersAuthor(s): Yuexin Sun, Chao Shi, Jiebing Yang, Shuangling Zhong, Zhanfeng Li, Lifeng Xu, Shengnan Zhao, Yan Gao, Xuejun CuiAbstractIn this present study, original, biodegradable, biocompatible, non-immunogenic and non-poisonous folic acid (FA) decorated reductive-responsive starch-based microcapsules (FA-RSMCs) were designed and fabricated via the sonochemical method for targeted delivery and controlled release of hydrophobic drugs. A green hydrophobic fluorescent dye, Coumarin 6 (C6), was encapsulated into the FA-RSMCs as a substitute of hydroph…

Publication date: Available online 10 August 2018Source: Sensors and Actuators B: ChemicalAuthor(s): Junli Zhang, Hongjuan Zhao, Jinjin Shi, Wei Liu, Kaixiang Zhang, Hongling Zhang, Zhenzhong ZhangABSTRACTNumerous studies have demonstrated tumor-derived exosomes (TEX) as an ideal biomarker for cancer. However, most present exosome detection methods were cumbersome and expensive, simple and specific detection of TEX in the blood still remained a challenging task. To solve the above problem, we found firstly that MUC1 was highly expressed on the surface of exosomes secreted by MCF-7 cells compared to other cells. Here, we de…

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