In August 2009, Dr. Claire Guest’s labrador began behaving peculiarly. Usually a gentle dog, Daisy — who Guest had been training to detect diseases with her keen sense of smell — refused to get into the car, and instead collided into Guest a few times before “prodding” her in the chest. Daisy’s strange behavior prompted Guest to check the area where the dog had nudged her. Tests later revealed that she had early-stage breast cancer. Her doctor told her she was “incredibly lucky”  to have found it so early. “All I could think was, what a difference Daisy has made,” Guest told The Telegraph in 2014. “I might have had to have aggressive chemotherapy. I might not have survived. That’s what made me decide: right, we’ve got to discover what’s going on.” Six years on, a cancer-free Guest is one of the leaders in the field of disease-detecting canines. Her organization, Medical Detection Dogs, recently gained approval from Britain’s National Health Service to conduct a landmark clinical trial to test dogs’ ability to sniff out prostate cancer cells. NBC News called the trial “groundbreaking.” Earlier studies have suggested that dogs’ incredible sense of smell can detect subtle odors known to be associated with many cancers, such as melanoma and cancers of the breast, bladder and lung. In the case of prostate cancer, Guest says initial tests have shown trai…

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Authors: Wang Y, Lan GB, Peng FH, Xie XB
Abstract
Renal transplantation is associated with an increased risk of cancers at multiple sites; however, the relationships between increased cancer risk and participant characteristics remain unclear. We searched PubMed, Embase, and the Cochrane Library to identify prospective observational studies performed up to July 2017. Totally 11 prospective studies reported data on 79,988 renal transplant recipients were included. Renal transplant recipients were found to display a higher risk of all cancers (standard incidence ratio [SIR]: 2.89; 95% CI: 2.13-3.91; P

Source: OncotargetCategory: Cancer & Oncology Tags: Oncotarget Source Type: research

Due to the collapse of the price of genetic testing and the FDA’s gradual ease of the regulatory environment, direct-to-consumer (DTC) genetic testing companies are booming. You can inquire your deoxyribonucleic acid about your ancestry, health risks, metabolism, and some start-ups even promise you to find true love or your kids’ talents. As the jungle of DTC companies is getting denser, more and more people ask me which genetic tests are worth the try. They love the possibility of getting access to their DNA but don’t know where to start. Here’s the DTC genetic testing kick-starter package!

Naviga…

Source: The Medical FuturistCategory: Information Technology Authors: Tags: Genomics 23andme ancestry DNA DTC future genetic test Genetic testing genetics Genome genome sequencing Health 2.0 Source Type: blogs

Conclusion: We observed a high adherence to counselling, genetic testing and active surveillance by men belonging to hereditary BC families. Male carriers of pathogenic DNA variants are at risk for several cancers and should be included in prospective follow-up studies.
PMID: 29456621 [PubMed]

Source: EcancermedicalscienceCategory: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

CONCLUSIONS: Well-designed and well-conducted RCTs have shown no beneficial effect of selenium supplements in reducing cancer risk (high certainty of evidence). Some RCTs have raised concerns by reporting a higher incidence of high-grade prostate cancer and type 2 diabetes in participants with selenium supplementation. No clear evidence of an influence of baseline participant selenium status on outcomes has emerged in these studies.Observational longitudinal studies have shown an inverse association between selenium exposure and risk of some cancer types, but null and direct relations have also been reported, and no system…

Source: Cochrane Database of Systematic ReviewsCategory: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

Author Affiliations open

1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada
2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
3 Universitat Pompeu Fabra (UPF), Barcelona, Spain
4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada
6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
7 Department of Economics, Brigham Young University, Provo, Utah, USA
8 Population Studies Division, Health Canada, Ottawa, Cana…

Source: EHP ResearchCategory: Environmental Health Authors: Tags: Research Source Type: research

ConclusionsWe observed excesses of total and specific cancers in both populations, although the strength of the evidence for causal relationships to WTC exposures is somewhat limited. Continued monitoring of this population is indicated. Am. J. Ind. Med. 59:709–721, 2016. © 2016 Wiley Periodicals, Inc.

Source: American Journal of Industrial MedicineCategory: Occupational Health Authors: Tags: Research Article Source Type: research

Background
Information on the impact of other cancers (OCs) in long-term survivors (LTSs) of chronic lymphocytic leukemia (CLL) is limited.

Patients and methods
Patients with CLL who survived>10 years were defined as LTSs of CLL. We calculated standardized incidence ratios (SIRs) to compare the incidence of OC in LTS of CLL versus the general population. A multivariable model was used to identify independent predictors of OC. Overall survival was analyzed as a function of the presence of OC.

Results
Among 797 LTSs of CLL, the cumulative frequency of OC was 36%, similar between 570 patients (72%) who required treatment…

Source: Annals of OncologyCategory: Cancer & Oncology Authors: Tags: hematologic malignancies Source Type: research

Conclusion.
Numbers of chronic cancer patients and possible time investment by primary care professionals in the case of a substitution scenario should not be a limiting factor for transition of follow-up from secondary to primary care, as most of the patients were diagnosed>5 years ago and a large proportion of these patients are already monitored in an existing chronic care programme.

Source: Family PracticeCategory: Primary Care Authors: Tags: Epidemiology Source Type: research

Abstract
Lymph node staging is important in many urologic malignancies. The lack of a sufficiently accurate noninvasive lymph node staging modality has proven to be challenging as most urologic malignancies rely on surgical lymph node removal for regional staging. Penile cancer has been a model disease for the development of the sentinel node concept, which has subsequently been successfully adapted to breast cancer and melanoma studies. Currently, the sentinel node technique is standardized in many centers and under development for new indications. The introduction of near-infrared cameras and fluorescence techni…

Source: Urologic OncologyCategory: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research

In August 2009, Dr. Claire Guest’s labrador began behaving peculiarly. Usually a gentle dog, Daisy — who Guest had been training to detect diseases with her keen sense of smell — refused to get into the car, and instead collided into Guest a few times before “prodding” her in the chest. Daisy’s strange behavior prompted Guest to check the area where the dog had nudged her. Tests later revealed that she had early-stage breast cancer. Her doctor told her she was “incredibly lucky”  to have found it so early. “All I could think was, what a difference Daisy has made,” Gues…





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