Acinetobacter baumanii was the most common cause of ventilator-associated pneumonia in ICU patients, and the risk of A. baumannii infection was significantly higher when airways were…

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AbstractUsing the Blanc reaction, new derivatives of camphor (1a–g) and camphor sulfonic acid (2a–g) were synthesized. Chemical structures of the new derivatives were supported by IR,1H-NMR,13C-NMR, and LC-MS/MS (ESI) spectrometric analyses. The new compounds (1a–g/2a–g) and the parent compounds (a–g) were tested for their antimicrobial efficacy against the following drug-resistant pathogens: methicillin-resistantStaphylococcus aureus (MRSA), multi-drug resistantKlebsiella pneumonia (MDR-Kb),Escherichia coli (FDA control),Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans (CLSI:…

erry Benvegnu

A phenylethanoid, two steroids, a flavone glucoside and a chalcone have been isolated for the first time from the stems of Calicotome villosa together with a previously isolated flavone glucoside. Their structures were determined by spectroscopic analyses (NMR, HRMS) as basalethanoïd B (1), β-sitosterol and stigmasterol (2), chrysine-7-O-β-d-glucopyranoside (3), chrysine 7-((6′′-O-acetyl)-O-β-d-glucopyranoside) (4) and calythropsin (5). The crude extracts and the isolated compounds (except 4), were evaluated for their antioxidant, antimicrobial (against two Gram-positive ba…

Source: MoleculesCategory: Chemistry Authors: Tags: Article Source Type: research

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Healthcare-associated infections (HAIs) occurring in patients treated in an intensive care unit (ICU) are serious complications in the treatment process. Aetiological factors of these infections can have an impact on treatment effects, treatment duration and mortality. The aim of the study was to determine the prevalence and microbiological profile of HAIs in patients hospitalized in an ICU over a span of 10 years. The active surveillance method was used to detect HAIs in adult patients who spent over 48 h in a general ICU ward located in southern Poland between 2007 and 2016. The study was conducted in complianc…

Background: Lower airway infections (LAI) occur frequently in children with a tracheostostoma. Whether airway pathogens are risk factors for LAI is not sufficiently studied.Methods: We retrospectively analysed patient records of tracheostomised children and young adults, who were treated between 2004 to 2014 in the childrens hospital of the University of Muenster, Germany. The correlation between lower airway pathogens and the number of LAI per year (Y) was assessed by Spearman correlation coefficient (r).Results: 78 patients were enrolled into the study and had a tracheostoma (median of 58.5 months (interquartile range (I…

Source: European Respiratory JournalCategory: Respiratory Medicine Authors: Tags: Paediatric Respiratory Infection and Immunology Source Type: research

Publication date: Available online 10 November 2017 Source:Saudi Pharmaceutical Journal Author(s): Nouf M. Al-Enazi, Amani S. Awaad, Mohamed E. Zain, Saleh I. Alqasoumi The antimicrobial, antioxidant, and anticancer activities of ethanolic extract of Laurencia catarinensis, L. majuscula and Padina pavonica were determined. The highest antibacterial activity; 23.40 ± 0.58 mm (00.98 µg/ml) and 22.60 ± 2.10 mm (03.90 µg/ml) were obtained against Klebsiella pneumonia by Laurencia catarinensis and Padina pavonica, respectively. However, Padina pavonica showed excellent antibacterial ac…

Conclusion The incidences of VAP, CAUTI, and CLABSI were high in ICUs, and multidrug-resistant organisms were the primary pathogens of NI. The implementation of targeted surveillance may determine the risk factors of NI so that effective intervention measures can be taken to reduce the incidence of NI in ICU patients.

Conclusions To reduce the risk of infection in hospitalized patients, DA-HAI surveillance is of primary importance because it effectively describes and addresses the importance and characteristics of the threatening situation created by DA-HAIs. The present surveillance shows high rates of ICU-onset DA-HAIs and high resistance patterns of organisms causing HAIs, representing a major risk to patient safety.

CONCLUSION: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi.
PMID: 29065840 [PubMed – as supplied by publisher]

Source: Medicinal ChemistryCategory: Chemistry Authors: Tags: Med Chem Source Type: research

Conclusions The incidence of VAP, CAUTI, and CLABSI were high in ICUs, and multi-drug resistant organisms were the primary pathogens of NI. The implementation of targeted surveillance can determine the risk factors of NI so that effective intervention measures can be taken to reduce the incidence of NI in ICUs patients.

ConclusionsInhaled TTO‐β‐CD powders have the advantages of portability, high stability, self‐administration, high lung deposition and good antipneumonic effect. It is a promising DPI for the treatment of fungal and bacterial pneumonia.

Source: Journal of Pharmacy and PharmacologyCategory: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research





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