Internal mammary chain radiation therapy for breast cancer is associated with increased cardiac toxicity, in particular when paired with anthracyclines.

Source: CancerNetworkCategory: Cancer & Oncology Authors: Source Type: news

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We present our clinical experience with DIBH in left breast and chest-wall irradiation using 3D optical surface tracking.

Source: Medical DosimetryCategory: Radiology Authors: Source Type: research

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ConclusionsThis trial will assess the cosmetic and normal tissue outcomes of external beam APBI delivered in 1  week for early-stage breast cancer.Trial registrationRegistration number: NCT02681107 (, registered February 2, 2016.

CONCLUSIONS: The DS was prognostic for risk and predicted RT benefit for DCIS patients. DS identified a clinically meaningful low risk group, and a group with elevated 10-year risks that received substantial RT benefit over baseline.
PMID: 30054280 [PubMed – as supplied by publisher]

Source: Clinical Cancer ResearchCategory: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

ConclusionThe results of the present study demonstrate that hypofractionation with integrated boost using intensity-modulated radiation therapy is an acceptable option that provides excellent local control and low toxicity.

Condition:   Inflammatory Breast Carcinoma Interventions:   Drug: Olaparib;   Radiation: Radiation Therapy Sponsor:   National Cancer Institute (NCI) Not yet recruiting

CONCLUSIONS: Post-mastectomy radiation therapy and implant-based reconstruction lead to minor under dosage of the target, due to the projection of the subcutaneous tissue in the presence of the implant. However, recurrence and survival rates were equally distributed among IBR+ and IBR- patients indicating that the overall treatment protocol used in our institution is safe.
PMID: 30055939 [PubMed – as supplied by publisher]

Patients with breast cancer receiving mastectomy in our institution are offered immediate breast reconstruction (IBR). IBR may have an impact on the optimisation of radiation therapy (RT). Therefore, we aimed to evaluate the clinical target volume (CTV) dose coverage when disregarding the dose received by the breast implant in women treated for breast cancer. Furthermore, to investigate the safety of immediate breast reconstruction (IBR) with an implant (IBR+) in terms of recurrence and survival compared to patients without an implant (IBR −).

Source: Radiotherapy and OncologyCategory: Radiology Authors: Tags: Original article Source Type: research

The objectives of this study were to (a) improve clinicians’ knowledge of screening, assessment, and prevention of RD in patients with breast cancer and (b) decrease the incidence of RD by 10% at a tertiary care cancer center.
METHODS: Center-wide standards of care were created and implemented. A retrospective chart analysis was performed before and after protocol implementation. An education session was used to analyze protocol effectiveness.
FINDINGS: Surveys completed by nurses (N = 11) before and after the education session demonstrated a significant increase in overall confidence in assessing RD. Statistical…

Source: Clinical Breast CancerCategory: Cancer & Oncology Authors: Tags: Clin J Oncol Nurs Source Type: research

CONCLUSIONSASTRO suitability criteria for APBI and RS were useful in making prognostic and therapeutic recommendations for patients considering IORT.

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