Chloe Pinder, 24, from Lincolnshire, was told she had acute lymphoblastic leukaemia last year. She underwent chemotherapy in a bid to fight the disease but was warned she could die within months.

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AbstractPurpose of ReviewTreatment options for patients with acute lymphoblastic leukemia (ALL) beyond standard chemotherapy have grown significantly in recent years. In this review, we highlight new targeted therapies in ALL, with an emphasis on immunotherapy.Recent FindingsMajor advances include antibody-based therapies, such as naked monoclonal antibodies, antibody-drug conjugates and bispecific T cell engaging (BiTE) antibodies, as well as adoptive cellular therapies such as chimeric antigen receptor (CAR) T cells. Apart from the above immunotherapeutic approaches, other targeted therapies are being employed in Philade…

We report the case of a 61-year-old Caucasian man with a history of alcoholic cirrhosis and numerous, large, and extensive basal cell carcinomas who was started on vismodegib, and presented 2 weeks later with altered mental status and hypercalcemia, hyperuricemia, and high LDH.

Secondary malignancies are broadly defined as a group of cancers arising after a previous malignancy and have become increasingly appreciated due to improvement in cancer survival. Therapy-related malignancies are a sub-group of secondary malignancies in which the exposure to prior chemotherapy or radiation therapy is instrumental to the establishment of the secondary cancer. Other than the role of previous therapies, underlying genetic predisposition, immunodeficiency states or simple coincidence have all also been invoked as potential causative factors for the development of secondary cancers [1].

Source: Leukemia ResearchCategory: Hematology Authors: Source Type: research

Acute lymphoblastic leukemia (ALL) is an aggressive hematologic malignancy treated with intensive chemotherapy[1]. In children ALL therapy was a success story [2], however in adults outcomes remain poor [3]. The poor prognosis of adult-ALL is attributed to the accumulation of poor prognostic features including, but not limited to, the higher frequency of poor-risk genomic subgroups, the lower tolerability to prolonged courses of intensive chemotherapy and the high therapy related mortality after hematopoietic cell transplantation (HCT) [4].

Source: Experimental HematologyCategory: Hematology Authors: Tags: Review Source Type: research

Publication date: Available online 30 July 2018Source: Beni-Suef University Journal of Basic and Applied SciencesAuthor(s): Shatha Abdul Wadood AL-ShammareeAbstractBackgroundThe role of Semicarbazide-sensitive amine oxidase (SSAO) in carcinogenesis is unknown; however, due to its function it may be involved in tumorigenesis via production of reactive aldehydes and hydrogen peroxide.ObjectiveThe study aimed to assess serum SSOA activity and to investigate the effect of cytotoxic chemotherapy on liver function in patients with acute lymphoblastic leukemia (ALL).Materials and MethodsSamples from 25 children with ALL were take…

CONCLUSION: Multiple ALL chemotherapy agents can affect postnatal brain development or heart function. This study provides a ranking of agents based on potential toxicity, and thus highlights a subset likely to cause side effects in early adulthood for further study.
PMID: 30054283 [PubMed – as supplied by publisher]

Source: Clinical Cancer ResearchCategory: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

For the GD-2008 ALL risk stratification based on age and initial WBC, 10 years of age and WBC 50×109/L can be used as cut-offs. Patients at high risk benefited from the GD-2008 ALL protocol. In addition, the impact of minimal residual disease on prognosis should be considered.

Weight gain is often observed in children with acute lymphoblastic leukemia (ALL) who undergo chemotherapy including steroids. An increase in body mass index (BMI)-standard deviation score (SDS) during induction therapy is reported as a risk factor for obesity after treatment. However, risk factors of an increase in BMI-SDS during induction therapy are not known. Ninety-six patients with ALL who were treated at our hospital between 1996 January and September 2013 were analyzed retrospectively. Daily body weight measurement was initiated in July 2005 in an attempt to control weight. Fifty-four patients were boys and 42 were…

In this study, the effects of two newly synthesized of colchicine derivatives were investigated on cell viability of cancerous and normal lymphocytes. The viability test was carried out by MTT assay. Apoptosis vs. necrosis was measured by double staining with annexin V/PI, and caspase-3 as the ultimate mediator of apoptotic measured through the colorimetric assay. Parameters of mitochondrial damage (ROS formation, MMP decline, mitochondrial swelling, and cytochrome c release following treatment by colchicine derivatives. By focusing on mitochondrial parameters, we showed that following treatment by two newly synthetized co…

CONCLUSION: The polymorphism of MTHFR C677T/A1298C may not be an important indicator for the accurate detection of side effects of chemotherapy after using MTX. More relative research is needed.
PMID: 30024839 [PubMed – as supplied by publisher]

Source: HematologyCategory: Hematology Tags: Hematology Source Type: research

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