Conclusion
It seems likely from this research that pioglitazone is linked to an increased risk of bladder cancer, although the overall chances of getting bladder cancer remain very low. While this type of research cannot prove that pioglitazone is the cause of the increased risk of bladder cancer, it is not easy to find a convincing alternative explanation for these results.
Previous research has already shown unexpectedly higher levels of bladder cancer among people taking pioglitazone, although other studies had found no such link. However, the size and the care with which this new study was carried out makes it convincing. Even so, we don’t know how the drug might cause bladder cancer. More work needs to be done to find out what action of the drug might trigger this specific type of cancer.
Doctors have already warned of a “small increased risk” of bladder cancer with this drug (PFD, 59kb). The European medicines regulator (the European Medicines Agency) advises that doctors do not use pioglitazone for people who have any history of bladder cancer, and that the risk of bladder cancer is checked before they start using the drug. Cautious use is advised for people with risk factors, such as increasing age, smoking, or history of chemotherapy or radiotherapy to the pelvic area.
For all people prescribed pioglitazone, the drug is stopped if blood sugar control does not improve within three to six months of use. However, for people who respond …

Source: NHS News FeedCategory: Consumer Health News Tags: Cancer Diabetes Medication Source Type: news

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