(Oregon State University) Usually thought of as a health detriment, elevated cholesterol may play a role in longer survival times for dogs with a common form of bone cancer.

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CONCLUSIONS Our study indicates that IL-6 induces strong immunosuppression in the CRC microenvironment by recruiting immunosuppression cells and impairing T cell infiltration. Inhibition of IL-6 enhanced the efficacy of anti-PD-L1 in CRC, providing a novel strategy to overcome anti-PD-L1 resistance in CRC.
PMID: 30087314 [PubMed – in process]

CONCLUSIONS We found that hsa_circ_0004458 promoted the progression of PTC by inhibition of miR-885-5p and activation of RAC1, and hsa_circ_0004458 may serve as a potential therapeutic target and biomarker for PTC.
PMID: 30086127 [PubMed – in process]

CONCLUSIONS Girinimbine, a carbazole alkaloid used in Chinese herbal medicine, inhibited the proliferation and cell migration of human ovarian cancer cells in vitro, in a dose-dependent manner, via the PI3K/Akt/mTOR and Wnt/β-catenin signaling pathways.
PMID: 30084434 [PubMed – in process]

In conclusion, simvastatin acts primarily by reducing prenylation to induce apoptosis and reduce osteosarcoma cell growth. Particularly enhanced activation of c-Jun seems to play a pivotal role in osteosarcoma cell death.
PMID: 29532878 [PubMed – in process]

Source: International Journal of OncologyCategory: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research

This study aimed to determine whether total serum cholesterol concentration was altered in dogs with osteosarcoma and, if so, to evaluate whether there was an association between total serum concentration and clinical outcomes of dogs with osteosarcoma. Sixty-four dogs with osteosarcoma were included in the study. The control population consisted of dogs with traumatic bone fractures (n=30) and healthy patients of a similar age and weight as those of the osteosarcoma cases (n=31). Survival analysis was done on 35 appendicular osteosarcoma patients that received the current standard of care. Statistical associations were as…

Source: Veterinary RecordCategory: Veterinary Research Tags: Research digest Source Type: research

Osteosarcoma (OS) is a highly aggressive pediatric cancer, characterized by frequent lung metastasis and pathologic bone destruction. Vascular endothelial growth factor A (VEGFA), highly expressed in OS, not only contributes to angiogenesis within the tumor microenvironment via paracrine stimulation of vascular endothelial cells, but also acts as an autocrine survival factor for tumor cell themselves, thus making it a promising therapeutic target for OS. CRISPR/Cas9 is a versatile genome editing technology and holds tremendous promise for cancer treatment. However, a major bottleneck to achieve the therap…

Source: BiomaterialsCategory: Materials Science Authors: Tags: Biomaterials Source Type: research

ABSTRACTPurposeTo investigate the potential of a reduction-sensitive and fusogenic liposomes, enabled by surface-coating with chotooligosaccharides (COS) via a disulfide linker, for tumor-targeted cytoplasmic drug delivery.MethodsCOS (MW2000-5000) were chemically tethered onto the liposomes through a disulfide linker (-SS-) to cholesterol (Chol). Doxorubicin (DOX) was actively loaded in the liposomes. Their reduction-sensitivities, cellular uptake, cytotoxicity, pharmacokinetics and antitumor efficacy were investigated.ResultsThe Chol-SS-COS/DOX liposomes (100  nm) had zeta potential of 33.9 mV and high drug load…

Publication date: Available online 25 May 2017 Source:Stem Cell Reports Author(s): Yangling Li, Miao Xian, Bo Yang, Meidan Ying, Qiaojun He Adriamycin-based combination chemotherapy is the standard first-line treatment for osteosarcoma, but tumor recurrence and metastasis occurs in most cases. Recent evidence suggests that microenvironmental stress such as chemotherapy can lead to the enrichment of cancer stem cells (CSCs), which result in cancer metastasis, recurrence, and drug resistance. However, the exact mechanisms underlying this phenomenon and how to target CSCs are still open questions. Herein, we report that Adri…

This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke.

To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti…

Source: Fight Aging!Category: Research Authors: Tags: Newsletters Source Type: blogs

Conclusions: Testing investigational agents in a panel of sarcoma cell lines along with molecular characterization may help identify new drugs worthy of clinical trial in sarcoma.Citation Format: Gurmeet Kaur, Eric Polley, Joel Morris, Thomas Silvers, Michael Selby, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Anne Monks, Annamaria Rapisarda, David Evans, Beverly A. Teicher. Osteosarcoma cell lines response to approved and investigational anticancer agents and statins along with gene and microRNA expression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research…

Source: Cancer ResearchCategory: Cancer & Oncology Authors: Tags: Experimental and Molecular Therapeutics Source Type: research

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