The expression of the histone methyltransferase EZH2 correlates with aggressive subtypes of cutaneous basal cell carcinoma, highlighting the possibility that EZH2 may be an actionable target in this malignancy, say researchers.
ConclusionAggressive SCC should be suspected in cases of persistent and relapsing purulent lesions in all patients.
Conclusion: BCCs were more often completely excised by dermatologists than by GPs and plastic surgeons. Dermatologists probably perform better because of their extensive training and high experience in BCC care. To minimize incomplete BCC excision, GPs should receive specific training before the shift of BCC care from secondary to primary care is justifiable.Dermatology
Treating periocular basal-cell carcinoma with vismodegib before surgery may reduce the size of the tumor, make the surgery less disfiguring and help preserve the eye, according to a single-center study.Reuters Health Information
Mapping is an essential step during Mohs micrographic surgery (MMS) since it allows tumors seen on histology to be tracked during surgery. Histologic findings are typically correlated to the clinical photo or to the hand-drawn map. Despite the increasing use of dermoscopy as an adjuvant tool to help identify basal cell carcinoma, mapping the dermoscopic findings before MMS has not been described to the author ’s knowledge. The author describes the “dermohscopy” mapping to better correlate dermoscopic findings with histology in MMS.
A 78-year-old Caucasian man presented with a 5 mm pink and black papule on his right back. The patient was receiving treatment for squamous cell carcinoma of the tongue and had previously received treatment for basal cell carcinoma. The patient was unaware of the lesion until it was identified by his oncology team, and he denied any associated symptoms. The remainder of the TBSE was unremarkable. Dermoscopic exam revealed central yellow-orange and black clods and small, gray dots which were encircled by a pigmented black-blue annulus.
Perineural invasion has recently been identified as a third route of basal cell carcinoma metastasis, along with lymphatic and hematologic spread. The incidence of perineural invasion in basal cell carcinomas is thought to be
Background: Differentiating between trichoepithelioma and basal cell carcinoma (BCC) is sometimes diagnostically challenging.
Incomplete basal cell carcinoma (BCC) excisions can pose a significant burden to patients and health care providers. These include the need for further treatment prolonged follow-up and recurrence of more aggressive tumor. We aimed to review our incomplete BCC excisions to identify ways to improve our patient outcome and services. Out of 665 non-Mohs Micrographic surgical excisions for BCCs from January to October 2016, in one of the U.K. skin centers 75 (11.2%) were incomplete. Procedures included excision with graft repair (38%), direct closure (35%), flap repair (8%) and double curettage (14%).
We report the case of a 61-year-old Caucasian man with a history of alcoholic cirrhosis and numerous, large, and extensive basal cell carcinomas who was started on vismodegib, and presented 2 weeks later with altered mental status and hypercalcemia, hyperuricemia, and high LDH.
Nevus sebaceus, most often seen on the head and neck, is not uncommon and usually present at birth. This lesion is comprised of abnormalities of the epidermis, hair follicle, sebaceous gland, and other adnexa. Most patients with nevus sebaceus, if they seek medical attention, often wait until the second to forth decade of life. Nevus sebaceus is frequently associated with development of other benign cutaneous neoplasms within the lesion, most commonly syringocystadenoma papilliferum and trichoblastoma-like proliferations (5% each).