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ConclusionDirect-acting antiviral therapies were well tolerated in patients older than 70 years. SVR12 rates in the elderly patient group were similar to those observed in younger patients. Differences in the prevalence of comorbidities between age groups warrant individualized attention with respect to drug–drug interactions and therapy adherence.The study was registered in the German Clinical Trials Register, DRKS-ID: DRKS00009717.
I spent 15 years as the Research Director for a community-based public health agency in Massachusetts. We offered substance abuse treatment and mental health services for people at risk for HIV; broader community-based HIV prevention and counseling and testing; housing services for people with HIV; and clinical case management. All of that is about saving the lives of individuals, and also preventing HIV transmission and protecting public health. In principle, if we do all that well and work at it hard enough, we can stop the epidemic.We were making progress. The number of new infections kept declining. The prevalence of H…
CONCLUSIONS In a mouse model of wound healing, KINDLIN-2 gene knockdown inhibited wound healing, and increased neovascular permeability in vivo.
PMID: 30070977 [PubMed – in process]
This study showed the interactions of FAdV, CIAV and LaSota after using contaminated NDV-attenuated vaccine, helping us to understand how the contaminated exogenous viruses cause infection and induce severe disease at a relatively low dose through the oral route.
Conclusion: Taken together, our results suggest that genetic variants in the intronic region of SSBP3 could be determinants in skin hydration of Korean females. SSBP3 represents a new candidate gene to evaluate the molecular basis of the hydration ability in individuals.
PMID: 30065583 [PubMed]
“I’ve always wanted to film the real ‘after party’ when the mom is passed out with her little kid in the background, or she gets into her car and drives drunk. It happens all the time.”
When I made the decision to quit drinking, one morning in June 2017 when my relentless hangover was surpassed only by my anxiety and self-loathing, I didn’t think about how sobriety would affect my role as a parent beyond the obvious positives: less time nursing a glass of wine and more time to engage with my kids; a clearer morning mind during the pre-school madness; more patience, less irritability. Mor…
Authors: Jia L, Guo H, Liu M, Gao Y, Zhang L, Li H, Xie S, Zhang N
Background: We aimed to construct an adenovirus expressing a cross-reactive fragment of the apical membrane antigen 1 (AMA1) antigen and evaluated the concomitant immune response in BABL/c mice, allowing protection against N. caninum and T. gondii infection.
Methods: The study was conducted in Agricultural College of Yanbian University, Yanji, Jilin, China In 2015-2016. Primers were designed using the AMA1 gene sequences of N. caninum (AB265823.1) and T. gondii (AF010264.1). After linearization of the plasmid ADV4-NcAMA1 and the framewo…
CONCLUSIONS: Barriers to developmentally necessary health care and health information that all adolescents need are compounded by the unique rural socio-environment and the involvement of multiple systems – family, school, peers, and healthcare providers – rooted within communities that may hinder adolescents from becoming thriving, contributing citizens. It is crucial that adults in rural communities seek to hear, strengthen, and empower young people through education, sharing of personal experiences and struggles, focusing adolescents’ time and energies on positive, pro-health activities, and providing positive role mode…
PMID: 29596407 [PubMed – in process]