Green tea may hold the key to preventing deaths from heart attacks and strokes caused by atherosclerosis, according to recent research published in the Journal of Biological Chemistry.

Scientists from Lancaster University and the University of Leeds have discovered a compound found in green tea, currently being studied for its ability to reduce amyloid plaques in the brain in Alzheimer’s disease, also breaks up and dissolves potentially dangerous protein plaques found in the blood vessels.

Atherosclerosis is the build-up of fatty material inside arteries which can reduce the flow of blood to the heart and brain. In advanced stages of the condition, a protein called apolipoprotein A-1 (apoA-1) can form amyloid deposits, similar in structure to those associated with Alzheimer’s disease. These deposits build up within atherosclerotic plaques. Here, they increase the size of the plaques, further restricting blood flow and making the plaques less stable, increasing the risk of a heart attack or stroke.

Researchers found that epigallocatechin-3-gallate (EGCG), most commonly associated with green tea, binds to the amyloid fibres of apoA-1. This converts the fibres to smaller soluble molecules that are less likely to be damaging to blood vessels.

“The health benefits of green tea have been widely promoted and it has been known for some time that EGCG can alter the structures of amyloid plaques associated with Alzheimer’s disease,” said David Middleton, Professor in Chemistry at Lancaster University. “Our results show that this intriguing compound might also be effective against the types of plaques which can cause heart attacks and strokes.”

Now, the team are working on finding ways of introducing effective amounts of EGCG into the bloodstream without it being necessary to drink large and potentially harmful quantities of green tea. This could involve modifying the chemical structure of EGCG, making it easier to be absorbed from the stomach and more resistant to metabolism, or developing new methods to deliver the molecule to the plaques – such as via an injection.

“The findings of this round of studies are very encouraging. We now need to apply the best scientific techniques to find how we can take the molecular ECGC element from green tea, and turn it into a functioning tool to combat life-limiting health issues,” said Professor Sheena Radford, Director of the Astbury Centre for Structural Molecular Biology at the University of Leeds and co-author of the research.

The research was funded by the British Heart Foundation and also part-funded by BBSRC.

ENDS

Notes to editors

Publication: Middleton et al, 2018, Journal of Biological Chemistry, Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin.

About the British Heart Foundation

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About BBSRC

The Biotechnology and Biological Sciences Research Council (BBSRC) is part of UK Research and Innovation, a non-departmental public body funded by a grant-in-aid from the UK government.

BBSRC invests in world-class bioscience research and training on behalf of the UK public. Our aim is to further scientific knowledge, to promote economic growth, wealth and job creation and to improve quality of life in the UK and beyond.

Funded by government, BBSRC invested £469 million in world-class bioscience in 2016-17. We support research and training in universities and strategically funded institutes. BBSRC research and the people we fund are helping society to meet major challenges, including food security, green energy and healthier, longer lives. Our investments underpin important UK economic sectors, such as farming, food, industrial biotechnology and pharmaceuticals.

 

 



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