In our Money Mic series, we hand over the podium to people with controversial views about money. These are their views, not ours, but we welcome your responses.

Today, one woman shares how an early-detection annual exam saved her life, and how the wise insurance decisions she made paid off — she only had a mere $100 tab for her entire treatment.

For all 44 years of my life, I’ve been diligent about my health.

I’ve never smoked, hardly ever drink, eat a healthy diet of mostly organic foods, and never forget my omega-3 supplements. I maintain a healthy weight, and lead an active lifestyle with my husband and two sons.

What’s more, I rarely get sick. If anyone in my house catches a cold or stomach bug, I suffer just a glancing blow, if anything at all.

In short, I’m the type of woman you might think would fare just fine if she skipped her yearly checkup. But I never have — a simple fact that saved my life.

The Calls That Changed It All …

In early 2014 I visited the doctor for my annual exam and Pap smear test — then mentally checked that health to-do off my list for the year.

Until a few days later, that is, when my phone rang while I was out shopping. I was surprised to see my ob-gyn’s number — but even more surprised by the news. My results came back slightly abnormal, and I needed to schedule a second test.

No problem, I thought, considering it just a minor inconvenience in my busy life.

A couple days after the follow-up appointment, the nurse called&nbsp…

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Authors: Ballestero Pérez A, García Pérez JC, Muriel A, Die Trill J, Lobo E
Abstract
BACKGROUND: a colonic stent as a bridge to elective surgery for left-sided malignant colonic obstruction is an alternative to the classical treatment. The aim of our study was to evaluate the recurrence rate as well as the morbidity and mortality of this treatment.
PATIENTS AND METHODS: patients admitted to the Emergency Department with left-sided malignant colonic obstruction between June 2006 and January 2014 were analyzed in a retrospective observational study. Patients who underwent self-expanding metal…

Publication date: Available online 6 August 2018Source: Radiation Physics and ChemistryAuthor(s): A. Noverques, G. Verdú, B. Juste, M. SanchoAbstractRadon is a gas produced from the radioactive natural disintegration of radium and uranium, which is present in soils and different building materials. Due to its gaseous nature, it emanates to the surface and penetrates both by convection and diffusion into the houses. According to recent studies, radon is considered the second leading cause of lung cancer, and it has prompted legislative changes to reduce exposure to this gas.In Spain, the current legislation -R.D. 783…

Mario Spacagna, 75, from Southampton, lives in constant pain after having a ten-inch sheet of surgical mesh placed internally to repair damage caused by a kidney tumour. This is his story.

Delfina Mota and her fiance, Paul Iheanachor filed a lawsuit for $5 million against the hospital that they claim gave Mota a C-section without anesthesia and then offered her a $25 gift card to ‘smooth it over.’

In the final part of our series, a leading neuroscientist – professor Matthew Walker, from the University of California – reveals how our brains use dreaming sleep to keep us healthy.

Publication date: Available online 6 August 2018Source: Life SciencesAuthor(s): M.D. Chanyshev, Y.V. Razumova, V.Y. Ovchinnikov, L.F. GulyaevaAbstractAimsThe purpose of the present study was to determine whether miR-21 regulates the human ACAT1 gene. We also assessed whether transfection of MCF-7 cells with miR-21 mimic/inhibitor leads to changes in ACAT1 mRNA/protein levels, cell proliferation rate, or apoptosis.Main methodsRegulation of ACAT1 3′UTR by miR-21 was evaluated using a dual-luciferase reporter assay. The effect of miR-21 on mRNA/protein levels of ACAT1 and PTEN (confirmed as an important target of miR-21…

Source: Life SciencesCategory: Biology Source Type: research

Rearrangements involving the neurotrophic receptor kinase genes (NTRK1, NTRK2, and NTRK3; hereafter referred to as TRK) produce oncogenic fusions in a wide variety of cancers in adults and children. Although TRK fusions occur in fewer than 1% of all solid tumors, inhibition of TRK results in profound therapeutic responses, resulting in Breakthrough Therapy FDA approval of the TRK inhibitor larotrectinib for adult and pediatric patients with solid tumors, regardless of histology. In contrast to solid tumors, the frequency of TRK fusions and the clinical effects of targeting TRK in hematologic malignancies are unknown. Here,…

Source: Journal of Clinical InvestigationCategory: Biomedical Science Authors: Source Type: research

Pulmonary hypertension (PH) is a heterogeneous and fatal disease of the lung vasculature, where metabolic and mitochondrial dysfunction may drive pathogenesis. Similar to the Warburg effect in cancer, a shift from mitochondrial oxidation to glycolysis occurs in diseased pulmonary vessels and the right ventricle. However, appreciation of metabolic events in PH beyond the Warburg effect is only just emerging. This Review discusses molecular, translational, and clinical concepts centered on the mitochondria and highlights promising, controversial, and challenging areas of investigation. If we can move beyond the “mounta…

Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed cancer initiation potential and enhanced chemoresistance. Cells at this slow-cycling status presented a distinctive nongenetic and cell-autonomous gene expression profile shared across different tumor types. We identified TET2 epigenetic enzyme as a key factor controlling SCCC numbers, survival, and tumor recurrence. 5-Hydroxymeth…

Source: Journal of Clinical InvestigationCategory: Biomedical Science Authors: Source Type: research

Brock Meister, 22, of Plymouth, Indiana, beat incredible odds and survived an internal decapitation in January, which is when the skull separates from the spinal cord.





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