(Cell Press) A link between malaria and Burkitt’s lymphoma was first described more than 50 years ago, but how a parasitic infection could turn immune cells cancerous has remained a mystery. Now, in the Aug. 13 issue of Cell, researchers demonstrate in mice that B cell DNA becomes vulnerable to cancer-causing mutations during prolonged combat against the malaria-causing Plasmodium falciparum.

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Source: Reuters: HealthCategory: Consumer Health News Tags: healthNews Source Type: news

Authors: Furusawa Y, Yamada S, Itai S, Nakamura T, Fukui M, Harada H, Kaneko MK, Kato Y
Abstract
Rat podoplanin (rPDPN) is a recognized lymphatic endothelial cell marker and is expressed on the podocytes of kidney and type I lung alveolar cells. rPDPN is a type I transmembrane sialoglycoprotein and induces platelet aggregation via the C-type lectin-like receptor-2 of platelets. It comprises four platelet aggregation-stimulating (PLAG) domains: PLAG1-3, present in the N-terminus, and PLAG4, in the center of the PDPN protein. Previously, we developed a mouse anti-rPDPN monoclonal antibody clone, PMab-2, by immunizing…

Chronic infection is one of the major causes of cancer, and there are several mechanisms for infection‐mediated oncogenesis. Some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. Some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral factors is important for malignant transformation. Coinfection with multiple agents is known to accelerate cancer development in ce…

Source: Cancer ScienceCategory: Cancer & Oncology Authors: Tags: SOLICITED REVIEW ARTICLE Source Type: research

This article is protected by copyright. All rights reserved.

Source: Cancer ScienceCategory: Cancer & Oncology Authors: Tags: Review Articles Source Type: research

A geographical and causal connection has long been recognized between malaria, Epstein–Barr virus (EBV) infection and Burkitt’s lymphoma (BL), but the underlying mechanisms remain obscure. Potential clues are that the malaria parasite Plasmodium falciparum selectively absorbs vitamin A from the host and depends on it for its biological activities; secondly, alterations in vitamin A (retinoid) metabolism have been implicated in many forms of cancer, including BL. The first author has proposed that the merozoite‐stage malaria parasite, emerging from the liver, uses its absorbed vitamin A as a cell membrane destabiliz…

Source: International Journal of CancerCategory: Cancer & Oncology Authors: Tags: Infectious Causes of Cancer Source Type: research

This article is protected by copyright. All rights reserved.

Source: International Journal of CancerCategory: Cancer & Oncology Authors: Tags: Research Article Source Type: research

Publication date: October 2016 Source:Current Opinion in Virology, Volume 20 Author(s): Ann M Moormann, Jeffrey A Bailey Burkitt lymphoma (BL) is >90% EBV-associated when this pediatric cancer is diagnosed in regions heavily burden by endemic Plasmodium falciparum malaria and thus has been geographically classified as endemic BL. The incidence of endemic BL is 10-fold higher compared to BL diagnosed in non-malarious regions of the world. The other forms of BL have been classified as sporadic BL which contain EBV in ∼30% of cases and immunodeficiency BL which occurs in HIV-infected adults with ∼40% of tumors con…

Burkitt lymphoma is unusually common in parts of Africa where malaria is widespread, but the reason for the association has been unclear. A new study suggests that parasitic infection triggers dramatic B-cell proliferation and increased expression of the enzyme activation-induced cytidine deaminase, which generates more potent antibodies—and causes mutations that lead to cancer.

Source: Cancer DiscoveryCategory: Cancer & Oncology Tags: News in Brief Source Type: research

Nature Reviews Cancer 15, 574 (2015).
doi:10.1038/nrc4020

Author: Sarah Seton-Rogers
Endemic Burkitt lymphoma occurs at a high incidence in areas with high levels of infection with the parasite Plasmodium falciparum, which causes malaria. However, whether Plasmodium influences lymphomagenesis is not clear. Robbiani et al. used Plasmodium chabaudi infection to induce chronic

Source: Nature Reviews CancerCategory: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research





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