This report summarizes cases of human adenovirus voluntarily reported through the National Adenovirus Type Reporting System, which aims to determine patterns of circulation for individual HAdV types.Morbidity &Mortality Weekly Report

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

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AbstractVascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a requirement for vascular sprouting. Identifying novel regulators of endothelial endocytosis could enhance our understanding of angiogenesis. Here, we evaluated the angiogenic potential of (CKLF-like MARVEL transmembrane domain 4) CMTM4 and assessed in which molecular pathway CMTM4 is involved during angi…

Source: AngiogenesisCategory: Molecular Biology Source Type: research

Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been tested as treatments for head and neck squamous cell carcinoma and non-small cell lung cancer. Although Ad-p53 gene therapy has yielded some interesting results when applied to prostate cancer, it has not been widely explored, perhaps due to current limitations of the approach. To achieve better functionality, improvements in…

Source: ClinicsCategory: General Medicine Source Type: research

Conclusion: Our findings suggested that rAAV9 can efficiently and safely transduce cardiomyocytesin vitro and/orin vivo. The rAAV9 serotype vector could constitute a powerful toolbox for future gene therapy of heart diseases.Cell Physiol Biochem 2018;48:1894 –1900

In this report, four nucleoside analogue compounds, octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- derivatives of adenine (ODE-HPMPA), cytosine (ODE-CDV), guanine (ODE-HPMPG), and 2,6-diaminopurine (ODE-HPMP-DAP), were evaluated against adenovirus type 14 and several other adenoviruses in vitro. All the ODE-nucleoside analogues demonstrated selective antiviral activities in neutral red uptake and virus yield reduction assays. Our data provide important insight into a series of compounds that might be advantageous in treating adenovirus infections.

by Niansheng Ju, Rundong Jiang, Stephen L. Macknik, Susana Martinez-Conde, Shiming Tang

Whereas optogenetic techniques have proven successful in their ability to manipulate neuronal populations—with high spatial and temporal fidelity—in species ranging from insects to rodents, significant obstacles remain in their application to nonhuman primates (NHPs). Robust optogenetics-activ ated behavior and long-term monitoring of target neurons have been challenging in NHPs. Here, we present a method for all-optical interrogation (AOI), integrating optical stimulation and simultaneous two-photon (2P) imaging of neurona…

This study is to investigate the association between viral load in children with human adenovirus (HAdV) pneumonia and disease seve…

Source: Virology JournalCategory: Virology Authors: Tags: Research Source Type: research

In conclusion, both hexon and fiber knob structures in HAdV-3 and HAdV-7 may be the proteins which induce neutralizing antibody responses and thus may be important for adenovirus vaccine and drug development.
PMID: 30096411 [PubMed – as supplied by publisher]

Source: Virus ResearchCategory: Virology Authors: Tags: Virus Res Source Type: research

In this report, four nucleoside analogue compounds, octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- derivatives of adenine (ODE-HPMPA), cytosine (ODE-CDV), guanine (ODE-HPMPG), and 2,6-diaminopurine (ODE-HPMP-DAP), were evaluated against adenovirus type 14 and several other adenoviruses in vitro. All the ODE-nucleoside analogues demonstrated selective antiviral activities in neutral red uptake and virus yield reduction assays. Our data provide important insight into a series of compounds that might be advantageous in treating adenovirus infections.
PMID: 30096340 [PubMed – as supplied by publisher]

Source: Antiviral ResearchCategory: Virology Authors: Tags: Antiviral Res Source Type: research

Preliminary evaluation of BioFire FilmArray® Gastrointestinal Panel for the detection of noroviruses and other enteric viruses from wastewater and shellfish.
Environ Sci Pollut Res Int. 2018 Aug 07;:
Authors: Gyawali P, Croucher D, Hewitt J
Abstract
The BioFire FilmArray® Gastrointestinal Panel was evaluated for the rapid detection of adenovirus, astrovirus, norovirus, rotavirus and sapovirus from influent and effluent wastewater and shellfish. The multiplex BioFire FilmArray® Gastrointestinal Panel compared well to singleplex qPCR/RT-qPCR methods for the detection of adenovirus, astroviru…

CONCLUSIONS In a mouse model of wound healing, KINDLIN-2 gene knockdown inhibited wound healing, and increased neovascular permeability in vivo.
PMID: 30070977 [PubMed – in process]





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