Older people who undergo cancer surgery are more likely than their younger counterparts to experience injuries and health issues such as falling down, breaking bones, dehydration, bed sores, failure to thrive and delirium. These age-related issues may lead to longer hospital stays, increased health care costs and a greater risk of death, a UCLA study found.
These problems can occur in addition to  post-surgery complications, making them much more challenging to handle and more difficult for people to recover from. The study also found that they are especially frequent in people who undergo major abdominal surgery for cancer.
The 18-month study, which appeared today in the Journal of Clinical Oncology, brings to light issues related to frailty and reduced functionality, conditions of the elderly that tend to be overshadowed by more common objects of study, such as survival rates and chemotherapy toxicity. The findings could lead to better care planning and, the researchers hope, better outcomes for patients whose age puts them at higher risk, said Dr. Hung-Jui Tan, the study’s first author and a fellow in urologic oncology at UCLA.
“The findings highlight the importance for older patients to discuss these potential events with their doctors as they prepare for surgery,” Tan said. “Now that the prevalence of such events is known, treatment approaches that keep these age-related health concerns in mind may be better applied in the future to better as…

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CONCLUSIONS: This model may help identify high-risk individuals with MDE and inform future research on risk of suicide.
PMID: 30085438 [PubMed – in process]

CONCLUSIONS: The findings from this study suggest generalist nurses are the frontline providers of care for mental health consumers in rural EDs and UCCs. Nurses feel ill-equipped for assessing and managing mental health presentations, relying heavily on local mental health teams and telephone triage who provide limited onsite support. The need to support nurses through training and mentoring relationships with community mental health teams is highlighted by this study in conjunction with improving the delivery of mental health services in rural areas.
PMID: 30081643 [PubMed – in process]

Source: Rural and Remote HealthCategory: Rural Health Tags: Rural Remote Health Source Type: research

Publication date: 15 November 2018Source: Biosensors and Bioelectronics, Volume 119Author(s): Dimithree Kahanda, Naveen Singh, David A. Boothman, Jason D. SlinkerAbstractThere is a great need to track the selectivity of anticancer drug activity and to understand the mechanisms of associated biological activity. Here we focus our studies on the specific NQO1 bioactivatable drug, ß-lapachone, which is in several Phase I clinical trials to treat human non-small cell lung, pancreatic and breast cancers. Multi-electrode chips with electrochemically-active DNA monolayers are used to track anticancer drug activity in cellul…

Publication date: Available online 6 August 2018Source: Biosensors and BioelectronicsAuthor(s): Duanping Sun, Jing Lu, Zhaofan Luo, Luyong Zhang, Peiqing Liu, Zuanguang ChenAbstractIn this work, a competitive and label-free electrochemical platform was performed for the ultrasensitive cytosensing of liver cancer cells based on DNA nanotetrahedron (NTH) structure and rolling circle amplification (RCA) directed DNAzyme strategy. The multifunctional nanoprobes were fabricated through a DNA primer probe, carboxyfluorescein (FAM) functionalized TLS11a aptamer and horseradish peroxidase (HRP) immobilized on the surfaces of the p…

Publication date: Available online 1 August 2018Source: Biosensors and BioelectronicsAuthor(s): Ruxiu Liu, Ningquan Wang, Norh Asmere, A. Fatih SariogluAbstractMicrofluidic devices can discriminate particles based on their properties and map them into different locations on the device. For distributed detection of these particles, we have recently introduced a multiplexed sensing technique called Microfluidic CODES, which combines code division multiple access with Coulter sensing. Our technique relies on micromachined sensor geometries to produce distinct waveforms that can uniquely be linked to specific locations on the …

Publication date: Available online 8 August 2018Source: Life SciencesAuthor(s): Xiaofeng Zhang, Fengshuang Li, Linzhong ZhuAbstractAimAccumulating studies have revealed that microRNA (miR)-93 may exert an oncogenic role in various cancers via inhibiting CDKN1A. However, the involvement of miR-93/CDKN1A axis in cervical cancer remains unclear. We aimed to investigate expression pattern, clinical significance and potential functions of miR-93/CDKN1A axis in cervical cancer.MethodsExpression levels of miR-93 and CDKN1A mRNA in 100 pairs of cervical cancer and matched non-cancerous tissue samples were detected by quantitative-…

Source: Life SciencesCategory: Biology Source Type: research

Publication date: September 2018Source: Journal of Bioscience and Bioengineering, Volume 126, Issue 3Author(s): Modong Tan, Satoshi Yamaguchi, Motonao Nakamura, Teruyuki NagamuneG-protein coupled receptors (GPCRs) are involved in many diseases and important biological phenomena; elucidating the mechanisms underlying regulation of their signal transduction potentially provides both novel targets for drug discovery and insight into living systems. A proton-sensing GPCR, ovarian cancer G protein-coupled receptor 1 (OGR1), has been reported to be related to acidosis and diseases that cause tissue acidification, but the mechani…

Less than half of women receiving trastuzumab underwent guideline-recommended cardiac monitoring, but observers suggest that more tailored monitoring may be the way forward.Medscape Medical News

(CNN) — The US Food and Drug Administration expanded the list of drugs being recalled that contain valsartan. The drug is used as a component in a set of drugs used to treat heart failure and blood pressure.
The FDA initially announced a valsartan recall in July after lab tests discovered that some drugs could have been tainted with a substance linked to higher risk of cancer. The drug had previously been recalled in 22 other countries. The expanded recall includes some drugs that contain valsartan and hydrochlorothisazide. Not all of the drugs containing valsartan were impacted.
N-nitrosodimethylamine or NDMA, the i…

In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells. To investigate the role therapeutic potential of miR-375, one kidney cancer cell line (A-498) was selected for further experimentation. It was observed that overexpression of miR-375 inhibits A-498 kidney cancer proliferation by induction of apoptosis. In addition, overexpression of miR-375 causes suppression of migration and invasion of the A-498 kidney cancers cells. Bioinformatic analysis revealed PDK1 to be putat…

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