Invasive aspergillosis in haematology New guidelinesWednesday, July 18, 2018 – 13:10Slide presentation

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Pulmonary syndromes following exposure to Aspergillus sp. have a variety of clinical and radiological manifestations. The radiological manifestations mirror the pathophysiological response to Aspergillus sp., which is linked closely to the patient’s immune status. The plethora of terms in the literature can be confusing and their application with relevance to radiological imaging may subsequently result in inadequate or non-specific classification. In this review, we aim to provide a simplified and up-to-date approach to the recognition of the imaging manifestations of pulmonary aspergillosis, using correlation with histop…

Source: Clinical RadiologyCategory: Radiology Authors: Tags: Pictorial Review Source Type: research

e; JP
Abstract
Aspergillus fumigatus is a saprotrophic fungus that continuously disseminates spores (conidia) into the environment. It is also the most common and opportunistic aerial fungal pathogen, causing allergic and chronic lung pathologies including the fatal invasive aspergillosis in immunocompromised patients. The pathobiology of aspergillosis is complex and depends on the competence of the host immune system. Moreover, A. fumigatus has become a model to study unique features of fungi. This includes the fungal cell wall, which not only acts as a rigid skeleton for protection against hostile environments b…

Source: MicrobiologyCategory: Microbiology Authors: Tags: Microbiology Source Type: research

AbstractPurpose of ReviewThe purpose of this review is to give an overview of recent findings on antifungal resistance inAspergillus fumigatus (the major causative agent of aspergillosis) and siblingAspergillus species, which can be hidden agents of aspergillosis.Recent FindingsAzole resistance by Cyp51A mutation inA.fumigatus is a growing problem worldwide. The resistance can occur in patients or in the environment. The former occurs by drug selection in the host, inducing mutations in Cyp51A. The latter is characterized by a tandem repeat in the promoter region ofcyp51A gene and mutation(s) in Cyp51A. Environmental resis…

Authors: Kemoi EK, Nyerere A, Bii CC
Abstract
The mainstay in prevention and treatment of aspergillosis is the use triazole drugs. In Kenya, the use of agricultural azole is one of the predisposing factors in development of resistance. One hundred fifty-six (156) experienced soils were collected from agricultural farms and cultured on Sabouraud DextroseAagar. The study isolated 48 yielded Aspergillus fumigatus and 2 A. flavus. All the isolates were subjected to antifungal susceptibility testing against three triazoles: posaconazole, voriconazole, and itraconazole. Out of the isolates, 3 had MIC of 32 and 1 had MIC …

Azole drugs are the first-line treatment option for invasive aspergillosis. Over the past few years, azole secondary resistance incidence in Aspergillus fumigatus strains is increasing. Similarly, the isolation of naturally azole resistant cryptic species of Aspergillus section Fumigati is starting to emerge. These issues became an important clinical concern considering that invasive aspergillosis treatment due to azole-susceptible strains are already difficult. Recently, an expert panel concluded that antifungal susceptibility testing of isolates should be performed if azole treatment is indicated.

ConclusionsThe results of the present study suggest that with implemented preventive measures, there is no increased risk for IA including azole resistance in immunocompromised patients during outdoor demolition work. Further prospective studies are needed to confirm our findings.

Understanding the composition and clinical importance of the fungal mycobiome was recently identified as a key topic in a “research priorities” consensus statement for bronchiectasis.
Patients were recruited as part of the CAMEB study: an international multicentre cross-sectional Cohort of Asian and Matched European Bronchiectasis patients. The mycobiome was determined in 238 patients by targeted amplicon shotgun sequencing of the 18S–28S rRNA internally transcribed spacer regions ITS1 and ITS2. Specific quantitative PCR for detection of and conidial quantification for a range of airway Aspergillus species …

Source: European Respiratory JournalCategory: Respiratory Medicine Authors: Tags: CF and non-CF bronchiectasis Original Articles: Cystic fibrosis and bronchiectasis Source Type: research

Analyst, 2018, Accepted Manuscript DOI: 10.1039/C8AN00841H, PaperWaqar M Ahmed, Pavlos Geranios, Iain R White, Michael Bromley, Oluwasola Lawal, Tamara Nijsen, Royston Goodacre, Nick Read, Stephen J Fowler Pulmonary aspergillosis can cause serious complications in people with a suppressed immune system. Volatile metabolites emitted by Aspergillus spp. have shown promise for early detection of pathogenicity. However, volatile profiles… The content of this RSS Feed (c) The Royal Society of Chemistry

Wednesday, July 18, 2018 – 13:13Slide presentation





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