In June, 2013, Lucy Crossley, then 27, from Leeds, suddenly developed a maddening itch all over her body, although she could find no rash or bites.
Publication date: Available online 6 August 2018Source: Journal of Geriatric OncologyAuthor(s): Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta FriedAbstractObjectivesTo examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster.Materials and MethodsParticipants were 170 BCS, stages I-III, 1–12 mo…
Ivan Shevchenko, Alexandr V. Bazhin
Speaking from the 23rd Congress of the European Hematology Association (EHA) 2018, held in Stockholm, Sweden, Paul Richardson, MD, of the Dana-Farber Cancer Institute, Boston, MA, tells us about isatu…
DiscussionThis was partly due to the fact that MSCs showed a potential to support tumor development. Moreover, the expression of mbTRAIL did not show caspase activation in adjacent tumor cells.
CONCLUSIONS: The results highlight the influences of friends and peers on beachgoers’ sun-protective behaviour for this young female adult cohort. Compared to previous findings among the general population, discrepancies in beliefs suggest interventions targeting this cohort should specifically focus on fashionable sun-safe images and motivation to reapply sunscreen. This article is protected by copyright. All rights reserved.
PMID: 30076670 [PubMed – as supplied by publisher]
Publication date: 30 October 2018Source: Biosensors and Bioelectronics, Volume 118Author(s): Hasan Motaghi, Sima Ziyaee, Masoud Ayatollahi Mehrgardi, Abolghasem Abbasi Kajani, Abdol-Khalegh BordbarAbstractIn the present manuscript, a closed bipolar electrode system integrated with electrochemiluminescence (ECL) detection has been introduced for sensitive diagnosis of human breast cancer cells (MCF-7). For sensitive and selective detection, the anodic pole of the bipolar electrode was modified with the AS1411 aptamer, a specific aptamer for the nucleolin, and treated by the secondary aptamer modified gold nanoparticles. The…
SKIN cancer symptoms are most commonly associated with moles on the skin. But this is only a sign of melanoma – non-melanoma skin cancer has a very different appearance. Are you at risk of either type?
ConclusionsThe data gathered throughout the analyses helps enlighten the structural basis for how naturally occurring mutations found in XPE patients impact on DDB2 and DDB1 function.General significanceOur data influence not only on the knowledge of XP but on the DNA repair mechanisms of NER itself.
This study establishes a bilevel optimization formulation that integrates the genome-scale metabolic model of hepatocytes, the Warburg hypothesis, and LC/MS experimental data to detect multiple-hit enzyme deficiencies that induce metabolic reprogramming in hepatocytes. A nested hybrid differential evolution algorithm was employed to solve the bilevel optimization problem. The results predicted dopa decarboxylase (DDC) to be an influential enzyme that causes oncogenesis. A cluster analysis of the flux variations for different enzyme deficiencies obtained through a flux variability analysis showed that DDC is a dominant over…