(Max Delbrück Center for Molecular Medicine in the Helmholtz Association) Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment is best for patients with Klatskin carcinoma, one type of bile duct cancer.
Patient and tumor free survival did not differ significantly between patients within Milan or University of California San Francisco criteria or beyond both criteria. Vascular invasion and poor differentiation are still the most influential factors for post-transplant long-term outcomes in HCC patients.
Patients with CC present a diagnostic challenge which often leads to the finding of more aggressive lesions on explant after LT, higher recurrence rates and worse post‐LT survival. Careful consideration of this diagnostic conundrum needs to be made before a clinical trial is undertaken. This article is protected by copyright. All rights reserved.
Conclusion: Interventional oncology and its image-guided intraarterial therapies continue to gain recognition as treatment options for primary and secondary liver cancers. Growing evidence supports their role as a standard of care alongside medical oncology, surgery, and radiation oncology.
PMID: 29230127 [PubMed]
In this study, we investigated the potential acquisition of CC-like traits during advanced development of HCC in mice. Primary and rare high-grade HCC developed in a genetic mouse model. A mouse model of highly efficient HCC invasion and metastasis via orthotopic transplantation of liver cancer organoids propagated from primary tumors in the genetic model was further developed. Invasive/metastatic tumors developed in both models closely recapitulated advanced human HCC, and displayed a striking acquisition of CC-related pathological and molecular features, which was absent in the primary HCC tumors. Our study directly demo…
In conclusion, the arguments supporting moderately loosened criteria for cancer seem more valid today than in the past. Transplant oncology is likely to represent a leading field in the near future, also because comorbidities and transplant‐related causes of death are better managed and often eliminated. Liver Transplantation 2017 AASLD.
This article is protected by copyright. All rights reserved.
CONCLUSIONS: Our study is one of only a few so far that have suggested improved accuracy of certain parameters under SSSO.
PMID: 29323061 [PubMed – in process]
This cohort study aimed to assess whether a high BMI in late adolescence is associated with an increased risk of severe liver disease and liver cancer in later life.
The researchers generally found a higher BMI was associated with an increased risk of severe liver disease, including liver cancer.
A diagnosis of type 2 diabetes during follow-up was associated with a further increased risk of severe liver disease, regardless of BMI at the start of the study.
This study included a very large population, and has used reliable sources of data for medical diagnoses and cause of death.
But there are limitations to …
In conclusion, liver transplantation is an important optio n for hepatobiliary malignancies; however, prospective studies are urgently needed to ensure the appropriate patient selection, organ allocation and living donation policies, and administration of antineoplastic immunosuppression.
Liver transplant is now an acceptable and effective treatment for specific nonhepatocellular malignancies. Worldwide, hilar cholangiocarcinoma accounts for 3% of all primary gastrointestinal malignancies and for 10% of primary hepatobiliary malignancies. For patients who have early-stage, unresectable cholangiocarcinoma, liver transplant preceded by neoadjuvant radiotherapy can result in tumor-free margins, accomplish a radical resection, and treat the underlying primary sclerosing cholangitis when present. Hepatic epithelioid hemangioendothelioma is a rare tumor of vascular origin with a variable maligna…