Classifying tumors for optimal therapeutic accuracy

Source: The ScientistCategory: Science Tags: Sponsored Videos Source Type: news

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A breast cancer survivor who ran one of the most notorious brands in fashion is now C.E.O. of Susan G. Komen, working to raise money for a cure.

Source: NYT HealthCategory: Consumer Health News Authors: Tags: Breast Cancer Fashion and Apparel American Apparel Inc Komen, Susan G, for the Cure Schneider, Paula Charney, Dov Source Type: news

Prehabilitation benefits among patients undergoing various oncological surgeries have been demonstrated. However, the effects of presurgical exercise and fitness on postoperative ipsilateral upper extremity recovery outcomes in patients with breast cancer surgery are less evident. A systematic review was performed to assess the effects of preoperative exercise and fitness on postmastectomy recovery. Systematic literature search was performed in 12 electronic databases. Study eligibility was accessed using the PICOS (Participants, Interventions, Comparison, Outcome and Study Design) criteria. Six eligible studies were found…

Publication date: 11–17 August 2018Source: The Lancet, Volume 392, Issue 10146Author(s): Hildegard Willer

Source: The LancetCategory: General Medicine Source Type: research

The objective was to quantify the relationship between deprivation and national breast cancer screening programme (NBCSP) participation on an ecological level in mainland France.Data from 4,805,390 women—living in 36,209 municipalities within 95 departments—participating in the 2013–2014 NBCSP were analysed using the French Deprivation Index (FDep). FDep population quintiles by municipality were computed to describe NBCSP participation according to deprivation. To better examine the relationship between continuous value of deprivation index and participation rates at the municipality level, we built a gen…

Source: Preventive MedicineCategory: International Medicine & Public Health Source Type: research

Tarah J. Ballinger, Jason B. Meier, Valerie M. Jansen

This study examined the psychosocial implications and the impact on risk perception of communicating personalized polygenic breast cancer risk to high-risk women. High-risk women with a personal history of breast cancer and an uninformativeBRCA1/2 result were genotyped in the Variants in Practice study for 22 breast cancer single nucleotide polymorphisms. Participants in the highest quartile of polygenic breast cancer risk were invited to receive their individual research results. Two personalized visual risk communication tools were used to facilitate communication of the polygenic information. Participants subsequently u…

Recently, great efforts have been made to use biosensors for the early diagnosis of cancer. Specifically, using a biomarker to detect H2O2 in physiological conditions is of great significance for understanding the signal transduction pathways and achieving early cancer diagnosis. In this work, we report an innovative H2O2 sensor that was fabricated by trimetallic AuPtPd nanocomposites platform on reduced graphene oxide (rGO) nanosheets with the modification of the rGO and trimetallic AuPtPd nanoparticles on a glassy carbon electrode (GCE) by physical adsorption. Transmission electron microscopy (TEM) and …

Source: TalantaCategory: Chemistry Authors: Tags: Talanta Source Type: research

In this study, a new electrochemical nanobiosensor for serum miR-199a-5p detection was designed by using modified glassy carbon electrode (GCE) with graphene oxide (GO) and gold nanoroad (GNR) on which a thiolated probe was immobilized. The electrochemical impedance method (EIS) was used to examine the electrochemical characteristics and behavior of nanobiosensor and for verifying the nanomaterial synthesis the scanning electron microscope (SEM) were applied, field emission scanning electron microscope (FE-SEM), UV-Vis spectrophotometry and energy dispersive spectroscopy (EDS). Optimum conditions were investigated for desi…

Source: TalantaCategory: Chemistry Authors: Tags: Talanta Source Type: research

Conclusion: Pneumonitis is a recognized toxic effect of T-DM1. While our sample size was small, the number of events was higher than described in the literature, which may be an artifact of referral bias. Future studies with a larger sample population may detect potential risk factors for toxicity.Case Rep Oncol 2018;11:527 –533

Conclusion: WBP2 overexpression is associated with the poor prognosis of TNBC patients and the miR-613-WBP2 axis represses TNBC cell growth by inactivating YAP-mediated gene expression and the EGFR/PI3K/Akt signaling pathway.Cell Physiol Biochem 2018;48:1968 –1982

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