A promising new approach to the treatment of acute myeloid leukemia (AML) has been discovered by a team of researchers. In their report, the investigators have identified a crucial dysfunction in blood cell development that underlies AML and show that inhibiting the action of a specific enzyme prompts the differentiation of leukemic cells, reducing their number and decreasing their ability to propagate the cancer.

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In conclusion, inhibition of ODC1 by DFMO was crucial in facilitating BCT‑100 treatment in lung adenocarcinoma that was partially mediated by depleting arginine and polyamines with consequent apoptosis.
PMID: 30066894 [PubMed – as supplied by publisher]

Source: Oncology ReportsCategory: Cancer & Oncology Tags: Oncol Rep Source Type: research

Publication date: August 2018Source: Seminars in Cancer Biology, Volume 51Author(s): Linn Gillberg, Andreas D. Ørskov, Minmin Liu, Laurine B.S. Harsløf, Peter A. Jones, Kirsten GrønbækAbstractOver the past few years it has become clear that vitamin C, as a provider of reduced iron, is an essential factor for the function of epigenetic regulators that initiate the demethylation of DNA and histones. Vitamin C deficiency is rare in the general population, but is frequently observed in patients with cancer. Genes encoding epigenetic regulators are often mutated in cancer, underscoring their central r…

Publication date: August 2018Source: The Lancet Haematology, Volume 5, Issue 8Author(s): Subhayan Chattopadhyay, Guoqiao Zheng, Amit Sud, Hongyao Yu, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki, Richard Houlston, Kari HemminkiSummaryBackgroundAlthough advances in the treatment of myeloid neoplasms have led to improved patient survival, this improvement has been accompanied by an increased risk of second primary cancer (ie, the risk of another cancer after myeloid neoplasia). We aimed to assess bi-directional associations between myeloid cancers and other cancers—ie, development of second prim…

Conclusions: This largest cytogenetic data in adult AML from Pakistan showed comparable prevalence of favorable
prognostic karyotype to international data. The prevalence of specific adverse prognostic karyotype was low.
PMID: 30049204 [PubMed – in process]

Publication date: Available online 29 July 2018Source: Pathology – Research and PracticeAuthor(s): Jialin Meng, Li Wanzhen, Meng Zhang, Hao Zongyao, Fan Song, Zhang Li, Chaozhao LiangAbstractObjectiveTransporter associated with antigen processing protein (TAP) is a heterodimer protein consist of TAP1 and TAP2, act a pivotal part in the immune surveillance. In recent days, controversial relationships were reported between TAP polymorphisms and cancer risk, thus, a systematic meta-analysis was performed to resolve this discrepancy.MethodsWe searched the PubMed, EMbase, Web of Science, CNKI and Wanfang databases, the cited re…

(University of Colorado Anschutz Medical Campus) Clinical trials at CU Cancer Center and elsewhere result in FDA approval of the drug ivosidenib for the treatment of adult patients with IDH1+ AML.

CONCLUSIONS: Holistic patient support-specific activities and adapted protocols made a measurable impact on patient outcomes. High survival outcomes of patients have been achieved despite relatively few receiving salvage therapies or stem cell transplant.

Source: Indian Journal of CancerCategory: Cancer & Oncology Authors: Source Type: research

Contributors : Bauke De Boer ; Janine Prick ; Maurien Pruis ; Peter Keane ; Maria R Imperato ; Jennifer Jaques ; Annet Z Brouwers-Vos ; Shanna M Hogeling ; Carolien M Woolthuis ; Marije T Nijk ; Arjan Diepstra ; Sebastian Wandinger ; Matthias Versele ; Ricardo M Attar ; Peter N Cockerill ; Gerwin Huls ; Edo Vellenga ; Andre B Mulder ; Constanze Bonifer ; Jan J SchuringaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensIntra-tumour heterogeneity caused by clonal evolution is a major problem in cancer treatment stratification. To address this problem, we performed label-free…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

Ras mutations are commonly observed in juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML). JMML and CMML transform into acute myeloid leukemia (AML) in about 10% and 50% of patients, respectively. However, how additional events cooperate with Ras to promote this transformation are largely unknown. We show that absence of the ubiquitin-specific peptidase 22 (USP22), a component of the Spt-Ada-GCN5-acetyltransferase chromatin-remodeling complex that is linked to cancer progression, unexpectedly promotes AML transformation in mice expressing oncogenic KrasG12D/+. USP22 deficiency in KrasG12D/+ …

Source: BloodCategory: Hematology Authors: Tags: Myeloid Neoplasia, Phagocytes, Granulocytes, and Myelopoiesis Source Type: research

Title: Tibsovo Approved for Acute Myeloid LeukemiaCategory: Health NewsCreated: 7/21/2018 12:00:00 AMLast Editorial Review: 7/23/2018 12:00:00 AM

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