Periodontal pathogen Tannerella forsythia linked to increased risk of esophageal adenocarcinoma
Publication date: September 2018Source: Clinica Chimica Acta, Volume 484Author(s): Song Mao, Xiaopeng Wang, Liangxia Wu, Dou Zang, Wenjing ShiAbstractBackgroundWe assessed the association between tissue klotho protein expression and the risk and progression of malignancies.MethodsWe searched the electronic databases for the studies regarding the relationship between tissue klotho protein expression and risk/progression of malignancies through January 2018. We calculated the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to evaluate the impact of tissue klotho protein expression on malignancies. A…
Clinical Significance of Human Papillomavirus Type 16 for Breast Cancer &Adenocarcinomas of Various Internal Organs and Alzheimer’s Brain with Increased β-amyloid (1-42); Combined Use of Optimal Doses of Vitamin D3 and Taurine 3 times/day Has Significant Beneficial Effects of Anti-Cancer, Anti-Ischemic Heart, and Memory &Other Brain Problems By Significant Urinary Excretion of Viruses, Bacteria, and Toxic Metals &Substances.
Acupunct Electrother Res. 2016;41(2):127-134
Authors: Omura Y
Human Papillomavirus type 16 (HPV-16) has a significant role in various cancers and Alzheime…
Little is known about the long-term outcomes of endoscopic resection (ER) in patients with esophageal adenocarcinoma (EA). In addition, the occurrence of metachronous EA after ER also remains unclear. The aim of this study was to clarify the long-term outcomes in Japanese patients with EA after ER, including those with esophagogastric junction cancer.
Conclusions Tissue klotho protein expression was associated with a lower risk and progression of malignancies. Klotho may be a protective factor against malignancies risk/progression.
BACKGROUND: We assessed the association between tissue klotho protein expression and the risk and progression of malignancies.
METHODS: We searched the electronic databases for the studies regarding the relationship between tissue klotho protein expression and risk/progression of malignancies through January 2018. We calculated the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to evaluate the impact of tissue klotho protein expression on malignancies. A fixed-effect model, or in the presence of heterogeneity, random- effect model was applied to calculate the combined ORs. …
Authors: Kaneko MK, Itai S, Yamada S, Kato Y
Esophageal cancer is one of the highly malignant cancers. It comprises two of the most common histological tumor types: squamous cell carcinoma (SCC) and adenocarcinoma. SCC accounts for about 90% of esophageal cancers. Despite developments in treatment strategies, the prognosis and survival rate remain poor. Podocalyxin (PODXL) is a highly glycosylated type-I transmembrane protein. It is expressed in normal tissues such as kidney, heart, breast, and pancreas. Upregulation of PODXL correlates with tumor progression, invasion, and metastasis. Therefore, this glyc…
by Marie C. Matrka, Katherine A. Cimperman, Sarah R. Haas, Geraldine Guasch, Lisa A. Ehrman, Ronald R. Waclaw, Kakajan Komurov, Adam Lane, Kathryn A. Wikenheiser-Brokamp, Susanne I. Wells
Esophageal cancer occurs as either squamous cell carcinoma (ESCC) or adenocarcinoma. ESCCs comprise almost 90% of cases worldwide, and recur with a less than 15% five-year survival rate despite available treatments. The identification of new ESCC drivers and therapeutic targets is critical for imp roving outcomes. Here we report that expression of the human DEK oncogene is strongly upregulated in esophageal SCC based on data in the cance…
Background: Adenocarcinoma of the esophagogastric junction (EGJ) is uncommon in Eastern countries, including Japan, but it is believed that the incidence of EGJ adenocarcinoma will increase in Asia in the future due to the decreasing incidence ofHelicobacter pylori infection. Endoscopic submucosal dissection (ESD) is a minimally invasive and curative treatment that allows precise pathological assessment.Summary: Magnifying endoscopy with narrow-band imaging may be useful for differential diagnoses and for delineating the cancer margin of EGJ adenocarcinoma, but subsquamous carcinoma extension, which is the invasion of EGJ …
Conclusions Patients with anastomotic leaks had increased variance in their preoperative oral and gastric flora. Microbiome analysis could help identify patients at higher risk for leak after esophagectomy.
CONCLUSIONS: Patients with anastomotic leaks had increased variance in their preoperative oral and gastric flora. Microbiome analysis could help identify patients at higher risk for leak after esophagectomy.
PMID: 29307454 [PubMed – as supplied by publisher]