[ANGOP] Benguela -At least 145,000 heads of cattle are expected to be vaccinated in the centre-west Benguela Province against anthrax and blackleg, aimed at allaying the spread of diseases, the provincial head of veterinary services, Gaspar Ingl ês, has announced.

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Publication date: June 2018Source: Meta Gene, Volume 16Author(s): P.N. Shivakumara, T.V. Aravindakshan, Thomas Naicy, K. Anilkumar, R. UmaAbstractToll like receptors (TLRs) are type 1 transmembrane proteins expressed in almost all cell types and activate the innate immune system. The present study involved characterization and differential transcriptional expression profiling of Toll-like receptor-2 gene in Vechur (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle of Kerala in response to anthrax vaccination. Sequence analysis revealed 2355 bp long TLR2 open reading frame encoding 784 amino acids with a signal…

Source: Meta GeneCategory: Genetics & Stem Cells Source Type: research

(MedPage Today) — Committee also heard data on cell-cultured influenza vaccines

Journal of Viral Hepatitis,Volume 25, Issue S2, Page 41-42, June 2018.

This article is protected by copyright. All rights reserved.
PMID: 29876918 [PubMed – as supplied by publisher]

Source: ImmunologyCategory: Allergy & Immunology Authors: Tags: Immunology Source Type: research

Conclusion/SignificanceOur data provide further evidence of EBOV exposure in individuals without EVD-like illness and, for the first time, demonstrate that these individuals have T cell responses that are stronger in magnitude compared to severe cases. These findings suggest that T cell immunity may protect against severe EVD, which has important implications for vaccine development.

Anthrax, plague and tularemia are three potent agents terrorists would be likely to use in an attack, according to the Centers for Disease Control and Prevention. Each is highly and quickly lethal to humans. But there are no licensed vaccines for tularemia and plague, and although there is an anthrax vaccine, it requires a burdensome immunization schedule and has severe side effects.Now, a UCLA-led group of researchers may have found a solution that, if found to be safe and effective in humans, could protect people from all three bacteria. The team used molecular engineering to develop vaccines against each that use a comm…

The Gaithersburg-based biotech just received approval to introduce its anthrax vaccine in five European countries, a move that brings the possibility of a new and important revenue stream.

Authors: D’Amelio E, Salemi S, D’Amelio R
Abstract
A brief history of vaccination is presented since the Jenner’s observation, through the first golden age of vaccinology (from Pasteur’s era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be dev…

Publication date: Available online 11 January 2018 Source:Meta Gene Author(s): P.N. Shivakumara, T.V. Aravindakshan, Thomas Naicy, K. Anilkumar, R. Uma Toll like receptors (TLRs) are type 1 transmembrane proteins expressed in almost all cell types and activate the innate immune system. The present study involved characterization and differential transcriptional expression profiling of Toll-like receptor-2 gene in Vechur (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle of Kerala in response to anthrax vaccination. Sequence analysis revealed 2355 bp long TLR2 open reading frame encoding 784 amino acids with a…

Source: Meta GeneCategory: Genetics & Stem Cells Source Type: research

CONCLUSION: The above findings provide compelling support to the thesis that adjuvants based on plasmids encoding protein aggregation domains disrupt the physiological features of the bone marrow elements.
PMID: 29303078 [PubMed – as supplied by publisher]

Source: Current Gene TherapyCategory: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research





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