Canadian drug discovery and development company Pascal Biosciences has executed an exclusive, worldwide licence option agreement with STC.UNM (STC) to purchase a therapeutic monoclonal antibody for B-cell precursor acute lymphoblastic leukaemia (BCP- …

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In this study, the inhibitory effect of Brucea javanica (BJ) on cell growth and inflammation was confirmed in human T-cell acute lymphocytic leukemia (T-ALL) cells, and its efficacy as an antileukemic agent was verified. Our results showed that BJ extract induced caspase-dependent apoptosis of T-ALL Jurkat cells through inhibition of the CK2-mediated signaling pathway, while exerting no significant cytotoxicity in normal peripheral blood mononuclear cells. Moreover, BJ extract suppressed the NF-κB signaling pathway, thus, inhibiting the interleukin (IL)-2 expression induced by phorbol 12-myristate 13-acetate (PMA) an…

Authors: Trussardi Fayh AP, de Carvalho Gomes C, Schroeder HT, Henrique de Lemos Muller C, Maria de Araújo Moura Lemos T, Krause M
Background: Acute lymphoblastic leukemia (ALL) is associated with higher levels of pro-inflammatory cytokines and oxidative stress. Recently, the levels of extracellular heat shock protein 72 (eHSP72) were found to be elevated in ALL, and its elevation associated with poor prognosis. Therefore, considering the possible role of eHSP72 as a modulator of the immunological system and metabolism, the aim of this study was to describe the response of eHSP72 to the induction ph…

Source: OncotargetCategory: Cancer & Oncology Tags: Oncotarget Source Type: research

B-ALL is the most common pediatric malignancy, accounting for ∼25% of cancers before 15 years of age. It represents a heterogeneous disease with morphologically identical leukemic cells seemingly arising from different biological mechanisms. Initial workup and evaluation of B-ALL has become increasingly complex partly due to the genetic abnormalities that ar e targets for specific therapy and play an important role in monitoring residual disease. Clinical management and risk stratification depend largely on the results of chromosomal abnormalities obtained using conventional cytogenetics and FISH testing, and a testing…

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Chromosome analysis and FISH demonstrate that ploidy changes, particularly gains in ploidy, are common in many tumors. However, with DNA copy number microarray or sequencing, all ploidy information is relative rather than exact. In this context, accurate ploidy assessment is based on software algorithms and the user’s experience in analysis of the data; FISH or karyotype information can serve in a supportive role for challenging cases. In rare cases of near-haploid genomes, it is more common for the predominant clone to be the doubling of the haploid line, as is the case for near-haploid acute lymphoblastic leukemia.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

T-cell acute lymphoblastic leukemia (T-ALL) represents a rare hematologic malignancy with poor outcomes in both children and adults. This leukemia typically features a primary abnormality that provides maturation arrest, in addition to secondary abnormalities associated with proliferation and cell survival. The wide-ranging scale of these genomic abnormalities requires multiple technical approaches, from classical karyotyping to chromosomal microarray and molecular sequencing, which confounds and may preclude complete characterization of T-ALLs.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Background: Whole genome high density (HD) SNP microarray analysis provides valuable insights into the cancer genome, unveiling important prognostic findings and therapeutic targets.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Genomic alterations in B-ALL are essential for disease diagnosis, prognosis, and treatment. We performed integrated genomic analysis on 136 pediatric B-ALL patients using the CHOP Comprehensive Hematological Cancer NGS Panel along with conventional cytogenetic studies. The panel interrogates 118 cancer genes for sequence and copy number variants (CNV) and 110 genes for known and novel fusions. Clinically significant genomic changes were identified in 89.7% of patients.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Contributors : Stefan Feske ; Shella S FleurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of T cell progenitors that in most patients is associated with activating mutations in the NOTCH1 pathway. Recent reports have indicated a link between Ca2+ homeostasis in the endoplasmic reticulum (ER), the regulation of NOTCH1 signaling and T-ALL. Here we investigated the role of store-operated Ca2+ entry (SOCE) in T-ALL. SOCE is a Ca2+ influx pathway that is mediated by the plasma membrane Ca2+ channel ORAI1 and its activators STIM1…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Publication date: May 2018Source: Saudi Journal of Biological Sciences, Volume 25, Issue 4Author(s): Anna Bogucka-Kocka, Christian Zidorn, Małgorzata Kasprzycka, Grażyna Szymczak, Katarzyna SzewczykAbstractPhenolic acid composition, antioxidant, and cytotoxic activities in leaves of four Kalanchoe (Crassulaceae) species were evaluated. Determination of phenolic acid contents were conducted by an optimized LC–ESI-MS/MS method. The results show that Kalanchoe daigremontiana Raym.-Hamet &H. Perrier (using ASE extraction) and Kalanchoe pinnata (Lam.) Pers. contain the highest amounts of phenolic acids, while Kalanc…

Publication date: Available online 26 May 2018Source: Journal de Mycologie MédicaleAuthor(s): A. Sharifpour, N. Gholinejad-Ghadi, R. Ghasemian, Z. Seifi, S.R. Aghili, E. Zaboli, R. Abdi, T. ShokohiAbstractThe patients with hematologic malignancies and hematopoietic stem cell transplantation (HSCT) recipients are at high risk for invasive fungal diseases (IFDs) mainly due to the severe and prolonged neutropenia related to high-dose chemotherapy. Voriconazole prophylaxis is recommended for possible IFDs. Mucormycosis is a fulminant infection, which may occur after voriconazole prophylaxis for invasive aspergillosis in…

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