Radiotherapy for prostate cancer may result in an increased risk of secondary malignancies of the bladder, colon, and rectum, according to findings of a systematic review and meta-analysis.

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Authors: Wang Y, Lan GB, Peng FH, Xie XB
Renal transplantation is associated with an increased risk of cancers at multiple sites; however, the relationships between increased cancer risk and participant characteristics remain unclear. We searched PubMed, Embase, and the Cochrane Library to identify prospective observational studies performed up to July 2017. Totally 11 prospective studies reported data on 79,988 renal transplant recipients were included. Renal transplant recipients were found to display a higher risk of all cancers (standard incidence ratio [SIR]: 2.89; 95% CI: 2.13-3.91; P

Source: OncotargetCategory: Cancer & Oncology Tags: Oncotarget Source Type: research

Conclusions -Lower limb arterial thrombosis was a marker of occult cancer, especially lung cancer, and was an adverse prognostic factor for mortality in common cancers.
PMID: 29540440 [PubMed – as supplied by publisher]

Source: Clinical Breast CancerCategory: Cancer & Oncology Authors: Tags: Circulation Source Type: research

Authors: Huang L, He K, Wang J, Yan J, Jiang Y, Wei Z, Zhang J, Li G, Huang D
Eukaryotic translation initiation factors 3B (eIF3b) is a subtype of the eIF3 category, which has been verified to be over-expressed in colon cancer, bladder, prostate cancers and glioblastoma due to its impact on the cellular activity of cancer cells. However, no related research on exploring the correlation of eIF3b gene expression with cell proliferation and apoptosis in chronic myeloid leukemia (CML) has been conducted until now. Our study showed that the expression of eIF3b mRNA in CML patients was higher compared with nonma…

Source: Oncology ResearchCategory: Cancer & Oncology Tags: Oncol Res Source Type: research

Early warning system for cancer return is possible Related items fromOnMedica Searching for a blood test to monitor ovarian cancer Lung cancer blood test Cheap blood test could boost prostate cancer treatment Underused cancer test could improve treatment of colon cancer Blood test may pick up bladder cancer ’s return before symptoms appear

ConclusionsUnder the assumptions of Mendelian randomization, there is a causal and negative association between serum triglycerides and risk of any cancer. Further, theHMGCR genetic variant might be associated with risks of prostate and breast cancers but the biological mechanisms behind these findings are unclear, as the LDLC IV was not associated with these cancers.

Conclusion Smoking, infectious agents, and betel nut chewing appear to be important contributors to the burden of cancer in Guam. Earlier onset of cancer in Guam suggests earlier age of exposure to key risk factors and/or a more aggressive pathogenesis. Contrasting cancer patterns within Guam and between Guam and Hawaii underscore the potential influence of genes, lifestyle, and environmental factors on cancer development and progression.

Source: Cancer EpidemiologyCategory: Cancer & Oncology Source Type: research

Author Affiliations open

1 McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Canada
2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain
3 Universitat Pompeu Fabra (UPF), Barcelona, Spain
4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
5 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada
6 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA
7 Department of Economics, Brigham Young University, Provo, Utah, USA
8 Population Studies Division, Health Canada, Ottawa, Cana…

Source: EHP ResearchCategory: Environmental Health Authors: Tags: Research Source Type: research

The objective herein is to test the specificity, affinity and biology efficacy of the humanized JAA-F11 (hJAA-F11). Using a 609 target glycan array, 2 hJAA-F11 constructs were shown to have excellent chemical specificity, binding only to TF-Ag alpha-linked structures and not to TF-Ag beta-linked structures. The relative affinity of these hJAA-F11 constructs for TF-Ag was improved over the mouse antibody, while T20 scoring predicted low clinical immunogenicity. The hJAA-F11 constructs produced antibody-dependent cellular cytotoxicity in breast and lung tumor lines shown to express TF-Ag by flow cytometry. Internalization of…

Source: NeoplasiaCategory: Cancer & Oncology Authors: Tags: Neoplasia Source Type: research

Finding could lead to new treatments Related items fromOnMedica Nasopharyngeal carcinoma and sinus cancer Underused cancer test could improve treatment of colon cancer Blood test may pick up bladder cancer ’s return before symptoms appear Tall men at higher risk of aggressive prostate cancer UK spends 20% less on cancer treatment than rest of EU

Offers tantalising prospect of being able to treat disease at earlier stage Related items fromOnMedica Blood test could predict likelihood of cancer returning Blood test to monitor effectiveness of cancer treatments Blood test could help predict response to lung cancer treatment Cheap blood test could boost prostate cancer treatment Underused cancer test could improve treatment of colon cancer

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