Syria’s presidency says first lady Asma Assad has begun treatment for breast cancer
[Govt of the Gambia] State House, Banjul, 7th August 2018 – The First Lady of the Republic, Her Excellency Fatoumatta Bah-Barrow has said the Gambia is making a steady progress in the fight against breast and cervical cancers, despite the high infection rates being registered across the sub region.
Improvements in cancer survivorship have led to increased recognition of treatment-related toxicities, some of which may not occur until years after the conclusion of treatment (1, 2). For breast cancer survivors, lymphedema is one of the most dreaded complications of surgery, radiation therapy, and taxane-based chemotherapy. Lymphedema involves a build-up of extracellular fluid within the upper extremity and results in swelling and, at times, chronic skin changes, fibrosis, loss of sensation, deformity, and pain (3).
This study was designed, performed, conducted and analyzed at the Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center.
This patient presents with stage IV, cT4dN3cM1 oligometastatic inflammatory breast cancer (IBC) (1). The initial treatment would be neoadjuvant chemotherapy (NAC). In the absence of progression with NAC, we would recommend mastectomy with axillary lymph node dissection and postmastectomy radiation therapy (PMRT). Given IBC’s penchant for locoregional recurrence and progression to carcinoma en cuirasse, an aggressive approach to PMRT is warranted, despite the presence of initial limited metastatic disease.
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We examined multiple ESR1 fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, ESR1 exons 1–6 were fused in frame to C-terminal sequences from the partner gene. Functional properties include estrogen-independent growth, constitutive expression of ER target genes, and anti-estrogen resistance. Both fusions activate a metastasis-associated transcriptional program, induce cellular motility, and promote the development of lung metastasis. ESR1-e6>YAP1- and ESR1-e6>PCDH11…
AbstractTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is difficult to treat since cells lack the three receptors (ES, PR, or HER) that the most effective treatments target. We have used a well-established TNBC cell line (MDA-MB-231) from which we found evidence in support for a phospholipase D (PLD)-mediated tumor growth and metastasis: high levels of expression of PLD, as well as the absence of inhibitory miRs (such as miR-203) and 3 ′-mRNA PARN deadenylase activity in these cells. Such findings are not present in a luminal B cell line, MCF-7, and we propose a new miR•PARN&…
Publication date: September 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 12, Issue 5Author(s): Natalia V. Yunusova, Irina V. Kondakova, Larisa A. Kolomiets, Sergey G. Afanas’ev, Anastasia Yu. Kishkina, Liudmila V. SpirinaAbstractMetabolic syndrome (MS) is one of the leading risk factors for the development of some common cancers (endometrial cancer, postmenopausal breast cancer, colorectal cancer). Currently, a drug-induced metabolic syndrome related with androgen deprivation therapy in patients with prostate cancer represents a serious medical problem. Not only MS, or its indi…