Taris Biomedical said today it is launching a new phase I trial of its TAR-200 gemcitabine releasing intravesical system designed to deliver drugs directly to the bladder for patients with non-muscle-invasive bladder cancer.
The phase 1b open-label study is slated to enroll 30 patients to explore whether continuous, local exposure to gemcitabine using TAR-200 is safe and tolerable in patients with intermediate risk non-muscle-invasive bladder cancer, the Lexington, Mass.-based company said.
“Non-muscle-invasive bladder cancer, which represents 70-75% of newly diagnosed cases, is a serious disease with a profound impact on the lives of patients. The current management of this cancer includes repeated surgical and pharmacological interventions, as well as lifelong monitoring. Despite these efforts, many patients are still at risk of recurrence and, in some cases, progression to MIBC. TAR-200 may ultimately offer a unique non-surgical approach in the management of this disease,” chief medical officer Dr. Christopher Cutie said in a press release.
The study will be conducted in Europe, and is the 2nd phase 1b trial of the TAR-200 for treating bladder cancer, Taris Biomedical said.
“The initiation of a second study of TAR-200 is another substantial milestone for our organization. If successful, these two studies are designed to demonstrate the potential utility of TAR-200 across the entire spectrum of bladder cancer. We are very excited to advance these programs …
CONCLUSIONS: QHT has proven to be a safe alternative for the treatment of intermediate and high risk NMIBC, with AE mainly grade 1-2. The AEs reported have little variation with respect to the dose of MMC used, presenting different “profiles” related to the device used for its administration. The treatments with QHTMMC are well tolerated, without adding significantly more AE than the instillations of MMC alone and presenting a better toxicity profile than those reflected in the literature with respect to the treatment with BCG.
PMID: 29745932 [PubMed – in process]
When I was in South Africa last year, I met a revolutionary winemaker…
His wine was completely organic. It had no toxins, and it contained powerful antioxidant properties.
It was infused with a local herb called rooibos, also known as “red bush.” You may have seen rooibos tea on supermarket shelves.
I immediately knew this wine should be made widely available in America — and I’m still hopeful a distributor will bring it here.
I enjoy a nice glass of red wine from time to time, but the trouble with most of the wines sold in America is that they’re loaded with dangerous chemicals.
Britain’s healthcare cost-effectiveness agency NICE, which decides if medicines should be used on the state health service, has decided Roche’s immunotherapy drug Tecentriq is worth using to treat certain patients with bladder cancer.Reuters Health Information
Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878
Received: 09 March 2017
Revised: 14 August 2017
Accepted: 16 August 2017
Published: 28 September 2017
Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: [email protected]
*Current address: UN…
Nature contact may offer a range of human health benefits. Although much evidence is already available, much remains unknown. A robust research effort, guided by a focus on key unanswered questions, has the potential to yield high-impact, consequential public health insights. https://doi.org/10.1289/EHP1663
Received: 26 January 2017
Revised: 12 May 2017
Accepted: 25 May 2017
Published: 31 July 2017
Address correspondence to H. Frumkin, Dept. of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Box 354695, Seattle, WA 98195-4695 USA; Telephone: 206-897-1723;…
Having a dog offers companionship, gives you an excuse to exercise, brings you happiness and provides entertainment. But did you know that owning a dog can also have potential health benefits, both mentally and physically, for you and your family? There is scientific evidence that touts some of the health perks of owning a pup.
Take a look at how these six ways having a dog could be good for your health.
1. Stay active
Dogs need to be exercised. They can’t be cooped up all day without having the chance to get up and run around. Having a dog encourages owners to take them for walks, play fetch, and get moving. And we…
A 77-year-old neurologically intact woman presented in hypertensive crisis (blood pressure [BP] 220/110 mm Hg) resulting in pulmonary edema. The patient had a history of remote (over 40 years) repaired aortic coarctation, breast cancer in remission, hypertension managed with 6 antihypertensive medications, and allergy to iodinated contrast. Her BP was reduced to as low as 134/26 mm Hg. Subsequently she developed acute paraplegia. Examination revealed nonlocalizing lower back and abdominal pain. Tibial pulses were absent, but extremities remained warm to touch. On neurologic examination, the abnormal findings were present o…
1. Improve heart health
Dogs don’t just fill your heart; they actually make it stronger. Studies show that having a canine companion is linked to lower blood pressure, reduced cholesterol, and decreased triglyceride levels, which contribute to better overall cardiovascular health and fewer heart attacks. What’s more, dog owners who do have heart attacks have better survival rates following the events.
2. Keep you fit and active
Health experts recommend that adults get about 2 hours and 30 minutes worth of moderate exercise per week. Dog owners are way more likely to hit that goal. “People love to be outs…
When was the last time you went in for your annual checkup? In honor of Men’s Health Month, I want to discuss the importance of paying attention to your body and visiting your primary care physician on a regular basis. If you’re healthy, a yearly visit might be sufficient but if you have a family history of any disease, have a pre-existing condition, or have suffered an injury, you may have to follow up with a doctor or specialist more often. A doctor’s visit is as much a part of a healthy lifestyle as clean eating and consistent exercise. If you have any issues or symptoms, especially any of the below, don’t be afraid to …
Stefano and I returned to Italy a couple of days ago. Those ten days we spent in the U.S.A. might well have been the worst days of my life thus far…worse even than when I received my cancer diagnosis…I mean, it was simply awful awful awful, every day, every minute of every day…
The “good” thing is that Stefano and I did get to Cape Cod in time to say goodbye to Mom, and in fact she is still alive. But I don’t think she will last very much longer. She is amazingly weak…The nurse practitioner, whom Stefano and I went to see shortly after we arrived, told us that &l…