Based on genes, the findings of this study allowed researchers to broadly classify colorectal cancer into four main types: CMS1, CMS2, CMS3 and CMS4.
To address the issue of inconsistent reporting of colorectal cancer types, researchers from different parts of the world formed an international consortium dedicated to large-scale data sharing and analysis.
They pooled pre-existing data on gene expression from colorectal cancer patients to assess the previously published colorectal cancer types.
While this study extends our understanding of the different types of colorectal cancer and in the future may lead to more targeted treatments for better outcomes, the results must be interpreted with caution.
The study does have strengths in its large sample size. However, although researchers have used sophisticated methods to aggregate this large data set, the samples were collected using different methods in different labs and at different points in time.
This means there may be some factors that were not taken into account when aggregating the different data sets, which might reduce the quality and reliability of the data.
Also, the clinical implementation of these results may take a long time as further research is required to fully understand these types of colorectal cancer.
Having a healthy diet that includes plenty of fibre-packed vegetables and fruits and exercising regularly is very important for reducing your risk of developing colorectal cancer.

Source: NHS News FeedCategory: Consumer Health News Tags: Cancer Genetics/stem cells Source Type: news

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This study was performed to determine the peri-operative outcomes of these patients and compare them with those of younger patients.
METHODS: In this retrospective analysis, 115 patients aged 70 years or more undergoing major surgery for head and neck cancers were matched with 115 patients aged 50-60 years, and univariate analysis was performed.
RESULTS: Elderly patients had a reduced performance status (p

Authors: Oh SH, Byun HJ, Oh SJ, Jun JY, Park JH, Lee JH, Lee DY, Lee JH, Yang JM
Drug induced lichen planus like eruption is an uncommon cutaneous adverse effect of several drugs. This appears symmetric eruption of erythematous or violaceous plaques resembling lichen planus on the trunk and extremities. A 50-year-old male presented with scaly, violaceous plaques and dusky brown macules on whole body. For four months, the patient was treated with olmutinib, an oral, third-generation epidermal growth factor receptor-tyrosine kinase inhibitor. In May 2016, olmutinib received its first global approval in South…

Source: Annals of DermatologyCategory: Dermatology Tags: Ann Dermatol Source Type: research

Authors: Jo SK, Lee JY, Lee Y, Kim CD, Lee JH, Lee YH
Hair graying is an obvious sign of human aging. Although graying has been investigated extensively, the mechanism remains unclear. Here, we reviewed previous studies on the mechanism of graying and seek to offer some new insights. The traditional view is that hair graying is caused by exhaustion of the pigmentary potential of the melanocytes of hair bulbs. Melanocyte dysfunction may be attributable to the effects of toxic reactive oxygen species on melanocyte nuclei and mitochondria. A recent study suggests that bulge melanocyte stem cells (MSCs) are th…

Source: Annals of DermatologyCategory: Dermatology Tags: Ann Dermatol Source Type: research

Publication date: Available online 4 August 2018Source: Redox BiologyAuthor(s): Jianbin Zhang, Xin Sun, Liming Wang, Yin Kwan Wong, Yew Mun Lee, Chao Zhou, Guoqing Wu, Tongwei Zhao, Liu Yang, Liqin Lu, Jianing Zhong, Dongsheng Huang, Jigang WangAbstractArtesunate (ART) is a prominent anti-malarial with significant anti-cancer properties. Our previous studies showed that ART enhances lysosomal function and ferritin degradation, which was necessary for its anti-cancer properties. ART targeting to mitochondria also significantly improved its efficacy, but the effect of ART on mitophagy, an important cellular pathway that faci…

Source: Redox BiologyCategory: Biology Source Type: research

STOMACH bloating could be caused by eating certain foods in your diet, or by having too much food in one go. While trapped wind is usually nothing to worry about, it may be caused by something serious, including cancer. These are the warning signs that you should see a doctor.

Publication date: Available online 4 August 2018Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Sunitha Chandran, Annie JohnAbstractOsteoporotic fracture treatment has become a skeletal reconstructive challenge due to accelerated bone turnover and impaired bone regeneration potential. Poor osseointegration ability of the osteoporotic bones usually results in implant pull out and failure. Adoption of conventional bone fracture treatment strategies like autografts and allografts have limited applications in such pathological conditions. Hence biomaterials functionalised with therapeutic ions or drugs may be ado…

Some bacteria may be getting better at handling alcohol. But that’s not a good thing.

CONCLUSIONS: In our publication, we could not find any link between familial background and the MSI status in GC patients. More detailed molecular and genetic analysis of subgroups of these patients is required.
PMID: 30071769 [PubMed – as supplied by publisher]

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling pathway induces apoptosis in cancer cells but not in normal cells. Therefore, this pathway has attracted attention regarding possible clinical treatment of cancer. However, many cancer cells demonstrate TRAIL resistance. To overcome this problem, small molecules that sensitize cancer cells to TRAIL are desired. Heterocyclic derivatives of the natural product, fuligocandin B (2), with activity for overcoming TRAIL resistance were synthesized, and their activity was evaluated. Of the synthetic molecules, the quinoline derivative (…

Source: Chemical and Pharmaceutical BulletinCategory: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research

The ability of tumors to escape from immune destruction is attributed to the protein-protein interaction between programmed cell death protein 1 (PD1) and programmed cell death ligand 1 (PDL1) proteins expressed by immune T cells and cancer cells, respectively. Therefore, pharmacological inhibition of the PD1-PDL1 interaction presents an important therapeutic target against a variety of tumors expressing PDL1 on their cell surface. Recently, five antibodies have been approved and several are in clinical trials against the PD1-PDL1 protein-protein interaction target. In contrast, there are very few reports…

Source: Chemical and Pharmaceutical BulletinCategory: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research

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