The latest and final in a series of congressionally mandated, biennial reviews by the Academies of the evidence of health problems that may be linked to exposure to Agent Orange and other herbicides used during the Vietnam War changed the categorization of health outcomes for bladder cancer, hypothyroidism, and spina bifida and clarified the breadth of the previous finding for Parkinson’s disease. The committee that carried out the study and wrote the report reviewed scientific literature published between Oct. 1, 2012, and Sept. 30, 2014. Read More

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Why don’t we have in vivo sensors sprinkled around our bodies? How long until we stop investing in temporary ex vivo sensors and start investing in permanent in vivo ones? What technological barriers are in the way? Where would they go for maximum usefulness? What would be the benefit?
Numerous medical device developers are investing in ex vivo sensors for a variety of applications, from wearables that support wellness, to outpatient tracking or non-invasive single-use diagnostics. I’ve been on a bit of a sci-fi kick lately, and it seems a pretty common motif that in the (fictional) futu…

Source: MDDICategory: Medical Devices Authors: Tags: Digital Health Source Type: news

ConclusionPre-operative MRI in cancer rectum is irreplaceable to assess initial staging and post-neoadjuvant therapy response thus improving surgical results.

The immunologic landscape of tumors has been continuously unveiled, providing a new look at the interactions between cancer cells and the immune system. Emerging tumor cells are constantly eliminated by the immune system, but some cells establish a long-term equilibrium phase leading to tumor immunoediting and, eventually, evasion. During this process, tumor cells tend to acquire more mutations. Bearing a high mutation burden leads to a greater number of neoantigens with the potential to initiate an immune response. Although many tumors evoke an immune response, tumor clearance by the immune system does not occur due to a …

Source: ClinicsCategory: General Medicine Source Type: research

Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed. Germline mutations in the BRCA 1/2 genes are the most well-known mechanisms of homologous recombination deficiency. However, other mechanisms, such as germline and somatic mutations in other homologous recombination genes and epigenetic modifications, have also been implicated in homologous recombination deficiency. The epidemiology and implications of these other mechanisms ne…

Source: ClinicsCategory: General Medicine Source Type: research

Gene therapy has been evaluated for the treatment of prostate cancer and includes the application of adenoviral vectors encoding a suicide gene or oncolytic adenoviruses that may be armed with a functional transgene. In parallel, versions of adenoviral vector expressing the p53 gene (Ad-p53) have been tested as treatments for head and neck squamous cell carcinoma and non-small cell lung cancer. Although Ad-p53 gene therapy has yielded some interesting results when applied to prostate cancer, it has not been widely explored, perhaps due to current limitations of the approach. To achieve better functionality, improvements in…

Source: ClinicsCategory: General Medicine Source Type: research

This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this endeavor, such as toxicity and supply. In this context, the development of these compounds will be discussed herein to illustrate, with successful examples provided by cytarabine, trabectedin, eribulin and brentuximab ve…

Source: ClinicsCategory: General Medicine Source Type: research

Cutaneous human papillomaviruses (HPVs) include β – and γ -HPVs, in addition to a small fraction of α -HPVs. β -HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to β -HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. In both immunosuppressed and immunocompromised individuals, cutaneous HPVs are ubiquitously disseminated throughou…

Source: ClinicsCategory: General Medicine Source Type: research

Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses. In recent years, studies have shown the importance of eicosanoids in the control of physiological and pathological processes associated with several diseases, including cancer. The polyunsaturated fatty acid predominantly metabolized to generate 2-series eicosanoids is arachidonic acid, which is the major n-6 polyunsaturated fatty acid found in animal fat and…

Source: ClinicsCategory: General Medicine Source Type: research

Publication date: Available online 9 August 2018Source: IDCasesAuthor(s): Mohamed Eisa, Kibrewessen Tefera, Anahita AlvanpourAbstractWe are presenting a case of Listeria monocytogenes spontaneous bacterial peritonitis (SBP) monomicrobial non-neutrocytic bacterascites (MNS) in a patient with malignant ascites secondary to cholangiocarcinoma who underwent peritoneal catheter placement. Listeria peritonitis is uncommon, with cancer patients at a higher risk. Listeria infection should be suspected in susceptible patients once there is no response to empiric antibacterial or if the initial culture report shows gram positive bac…

Source: IDCasesCategory: Infectious Diseases Source Type: research

The latest and final in a series of congressionally mandated biennial reviews of the evidence of health problems that may be linked to exposure to Agent Orange and other herbicides used during the Vietnam War changed the categorization of health outcomes for bladder cancer, hypothyroidism, and spina bifida and clarified the breadth of the previous finding for Parkinson’s disease.





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