Inadequate vitamin D levels are linked with a range of health problems, and researchers have now established a link with bladder cancer.

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PMID: 30067125 [PubMed – as supplied by publisher]

Authors: Otieno CN, Park S
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Chemotherapeutic resistance is one of the main obstacles for cancer remission. To understand how cancer cells acquire chemotherapeutic resistance, biochemical studies focusing on drug target alteration, altered cell proliferation, and reduced susceptibility to apoptosis have been performed. Advances in nano-mechanobiology showed that the enhanced mechanical deformability of cancer cells accompanied with cytoskeletal alteration is a decisive factor for cancer development. Furthermore, atomic force microscopy (AFM)-based nano-mechanical studies showed that chemotherapeutic treatmen…

Source: Biological ChemistryCategory: Chemistry Tags: Biol Chem Source Type: research

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Dynamins are essential as membrane remodelers in various cellular processes, like receptormediated endocytosis, synaptic vesicle recycling, and spermatogenesis. Moreover, dynamin is involved in the internalization of numerous viruses and in the motility of several cancer cell lines. As tools for dissecting the underlying mechanisms of these important biological processes and as potential future therapeutics, small molecules have been developed in the last two decades that modulate the functions of dynamin. In this review we give an overview of the compound classes that are…

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PEOPLE deficient in the sunshine vitamin are at greater risk of bladder cancer, a new study warned.

PEOPLE deficient in vitamin D – the vitamin people can get from sunshine – are at greater risk of bladder cancer, scientists have warned.

Vitamin D deficiency is associated with an increased risk of developing bladder cancer, according to a systematic review of seven studies. Though further clinical studies are needed to confirm the findings, the study adds to a growing body of evidence on the importance of maintaining adequate vitamin D levels.

This study aimed to investigate association of plasma 25-hydroxyvitamin D (25-OHD) with urothelial bladder cancer (UBC) risk in Tunisians. A case-control study included 250 patients with UBC and 250 healthy controls. Plasma 25-OHD was assessed by a competitive chemiluminescence immunoassay. Vitamin D deficiency and insufficiency were defined as 25-OHD

Source: Nutrition and CancerCategory: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research

Abstract
The aim of the study was to test whether the VDR FokI polymorphism is associated with the risk of urothelial bladder cancer (UBC) in Tunisians. The study included 200 unrelated patients with UBC and 200 healthy controls. Genotyping of the VDR FokI polymorphism was determined by PCR-RFLP method. Plasma 25-hydroxyvitamin D concentrations were measured by immunoassay. Binary logistic regression model was applied to test how the association of VDR FokI polymorphism is independent of potential confounding factors. Genotype distribution (FF, 45 vs. 55 %; Ff, 52.1 vs. 47.9 %, and ff, 12 vs. 5.5 %,…

Source: Tumor BiologyCategory: Cancer & Oncology Source Type: research

Authors: Wu X, Zhou T, Cao N, Ni J, Wang X
Abstract
The vitamin D endocrine system regulates a broad variety of independent biological processes, and its deficiency is associated with rickets, bone diseases, diabetes, cardiovascular diseases, and tuberculosis. Cellular and molecular studies have also shown that it is implicated in the suppression of cancer cell invasion, angiogenesis, and metastasis. Sunlight exposure and consequent increased circulating levels of vitamin D are associated with reduced occurrence and a reduced mortality in different histological types of cancer, including those resident in the skin,…

Source: Oncology ResearchCategory: Cancer & Oncology Tags: Oncol Res Source Type: research





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