New antibiotics need to be developed urgently to combat 12 families of bacteria, the World Health Organization said on Monday, describing these “priority pathogens” as the greatest threats to human health.
The United National health agency said many of these bacteria have already evolved into deadly superbugs that are resistant to many antibiotics.
The bugs “have built-in abilities to find new ways to resist treatment” the WHO said, and can also pass on genetic material that allows other bacteria to become drug-resistant.
Governments need to invest in research and development (R&D)if new drugs are to be found in time, because market forces cannot be relied upon to boost the funds needed to fight the bugs, it said.
“Antibiotic resistance is growing, and we are fast running out of treatment options,” the WHO’s assistant director-general for health systems and innovation, Marie-Paule Kieny, said.
“If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time.”
In recent decades, drug-resistant bacteria, such as Staphylococcus aureus (MRSA) or Clostridium difficile, have become a global health threat, while superbug strains of infections such as tuberculosis and gonorrhea are now untreatable.
The WHO has previously warned that many antibiotics could become totally redundant this century, leaving patients exposed to deadly infections and threatening the future of medicine…

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Authors: Alajmi MF, Mothana RA, Al-Rehaily AJ, Khaled JM
Abstract
Tuberculosis (TB) remains a common deadly infectious disease and worldwide a major health problem. The current study was therefore designed to investigate the in vitro antimycobacterial activity of different extracts of Alpinia galanga and Tinospora cordifolia. Moreover, a safety assessment for both plants was carried out. Dichloromethane and ethanolic extracts of each plant were examined against H37Rv INH-sensitive and resistant INH strains of Mycobacterium tuberculosis. The safety assessment of both plants has been performed through in vivo acute a…

In this report, we present an immunocompetent 7-year-old male with a complex medical history diagnosed with cutaneous Mycobacterium tuberculosis after multiple ventriculo-peritoneal shunt (VPS) revisions. This case of cutaneous tuberculosis, in an immunocompetent patient is remarkable in its uncharacteristic presentation with no obvious source of tuberculosis infected contacts or travel history.

Source: IDCasesCategory: Infectious Diseases Source Type: research

I was an active kid, running at the speed of sound and light, rarely stopping to catch my breath. I attribute part of that to a diagnosis of asthma that I would not allow to slow me down. I felt a need to prove that I could keep up with my peers, not wanting to be thought of as weak. School, swim team, Girl Scouts, Hebrew School, volunteering, youth group as well as time with friends, kept me busy. Seems it was preparation for my current lifestyle.
Nearing 60, I work as a therapist, journalist, minister, editor, teacher, speaker and facilitator. Add to it various volunteer activity, and a full, rich social life with famil…

Source: World of PsychologyCategory: Psychiatry & Psychology Authors: Tags: Habits Happiness Health-related Motivation and Inspiration Personal Technology Source Type: blogs

From 2014 through 2017, there was an increase in US poison control calls related to the intentional abuse and misuse of tianeptine, an unapproved antidepressant drug, the US Centers for Disease Control and Prevention said in a report on Thursday.

Source: CNN.com – HealthCategory: Consumer Health News Source Type: news

Conclusions: Microorganisms associated with SWI in our study were mainly commensals, with the most common pathogen being Staphylococcus epidermidis.
PMID: 30069187 [PubMed]

Abstract
To explore the role of the abnormal expression of the bile salt export pump (BSEP) and multidrug resistance protein 2 (MRP2) in isoniazid (INH)-induced liver injury, we assessed the liver injury induced by INH in rats and HepG2 cells in vitro. The regulatory pathways via Sirtuin 1 (SIRT1) and farnesoid X receptor (FXR) were also determined. Rat liver injury was assessed by histopathological and biochemical analysis and HepG2 cytotoxicity was assessed by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. The levels of protein were determined by Western blot. The results indicated th…

Source: Biological and Pharmaceutical BulletinCategory: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research

Publication date: Available online 24 July 2018Source: Fish &Shellfish ImmunologyAuthor(s): Jie Du, Huanxi Zhu, Chunlei Cao, Yan MaAbstractPattern recognition proteins (PRPs) activate the innate immune system in invertebrates, and lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) is an important PRP with various biological functions. Here, the open reading frame (ORF) of Macrobrachium rosenbergii LGBP (MrLGBP) was cloned into plasmid vector pHAC181, then integrated into downstream of the GAL1 promoter of Saccharomyces cerevisiae strain GAL1-ScRCH1 via homologous recombination, followed by its expression …

Conditions:   Childhood Pneumonia;   Mycoplasma Pneumonia;   Antibody-secreting Cells;   Enzyme-linked Immunospot (ELISpot);   Diagnosis Intervention:   Diagnostic Test: Enzyme-linked immunospot (ELISpot) assay [Blood] Sponsor:   University Children’s Hospital, Zurich Completed

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

A 23-year-old woman was referred to the tertiary centre with acute kidney injury and severe metabolic alkalosis following an accidental ethylene glycol poisoning. The patient had been treated with continuous haemodiafiltration and regional citrate anticoagulation, and a tracheostomy was performed due to pneumonia. Besides severe metabolic alkalosis and hypernatremia, the laboratory tests revealed total protein of 108 g/L on admission to the tertiary centre. The haemodiafiltration with regional citrate anticoagulation continued with parallel correction of the alkalosis and normalisation of the total plasma protein. The trac…

Conclusion: VZV infection occurs in a range of clinical scenarios, sometimes presenting only with mild symptoms, but in some other setting it can result in severe AKF even in healthy kidneys. Acute VZV infection can lead to isolated, clinically significant kidney failure. The administration of continuous renal replacement therapy and adjusted doses of acyclovir has a favorable effect on the course of the infection, with complete recovery of kidney function.Case Rep Nephrol Dial 2018;8:130 –137





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