XI Reuni ón de la Sociedad Española de Medicina Tropical y Salud InternacionalDate: Monday, July 30, 2018Year: 2018Location: Seville, SpainContent-type: current_conferences

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We report on 24 p40phox-deficient patients from 12 additional families in 8 countries. These patients display 8 different in-frame or out-of-frame mutations of NCF4 that are homozygous in 11 of the families and compound heterozygous in another. When overexpressed in NB4 neutrophil-like cells and EBV-transformed B cells in vitro, the mutant alleles were found to be LOF, with the exception of the p.R58C and c.120_134del alleles, which were hypomorphic. Particle-induced NADPH oxidase activity was severely impaired in the patients’ neutrophils, whereas PMA-induced dihydrorhodamine-1,2,3 (DHR) oxidation, which is widely u…

Source: Journal of Clinical InvestigationCategory: Biomedical Science Authors: Source Type: research

Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.8b02117

Source: Journal of Agricultural and Food ChemistryCategory: Food Science Authors: Source Type: research

Publication date: Available online 3 August 2018Source: Journal of Molecular StructureAuthor(s): Muhammad Danish, Ayesha Bibi, Khola Gilani, Muhammad Asam Raza, Muhammad Ashfaq, Muhammad Nadeem Arshad, Abdullah Mohamed Asiri, Khurshid AyubAbstractTwo carboxylate esters (methyl: (I) and ethyl: (II)) of 4-{(4-methylphenylsulfonamido)- methyl}cyclohexanecarboxylic acid (sulfonamide) were synthesized and characterized by FTIR and X-ray crystallography. DFT studies were conducted in order to optimize the structures using Gaussian software which confirmed the bond angels and bond lengths obtained from single crystal analysis. Bo…

Prasad Dasari, Iordana A. Shopova, Maria Stroe, Dirk Wartenberg, Hans Martin-Dahse, Niklas Beyersdorf, Peter Hortschansky, Stefanie Dietrich, Zolt án Cseresnyés, Marc Thilo Figge, Martin Westermann, Christine Skerka, Axel A. Brakhage, Peter F. Zipfel

Similarity evaluation of complicated chromatographic profiles is a potential proticol for the identification and quality control of herbal medicinal products to ensure their biological activity. In this work, a high-performance liquid chromatography method was established for controlling the batch quality of the extract from Portulaca oleracea L. By using this method, the coefficients of correlation of the similarity of 10 batches extract of Portulaca oleracea L. were≥0.97. The 10 batch extracts from Portulaca oleracea L. possessed stable antiproliferative activity in Aspergillus flavus. The antiprolif…

Source: Biomedical Chromatography : BMCCategory: Biomedical Science Authors: Tags: Biomed Chromatogr Source Type: research

Publication date: Available online 2 August 2018Source: Journal of Microbiological MethodsAuthor(s): Balaji VenkatesagowdaAbstractThe ability of enzymatic Kraft Lignin (KL) demethylation was determined using catechol and ferric ion coordination (catechol-Fe3+ complexes) by reduction of Fe3+ to Fe2+ and formation of mono, bis- and/or tris-catechol-Fe3+ complexes has been investigated to identify enzyme that can strip-off O-methyl groups from lignin such as O-demethylase. To detect fungal demethylation and release of catechol-like structures, these were demonstrated using catechol, gallic acid and caffeic acid as standard mo…

Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.8b00382

Source: Journal of Natural ProductsCategory: Biochemistry Authors: Source Type: research

Although iron and copper are coordinately regulated in living cells, the homeostatic effects of each of these metals on the other remain unknown. Here, we show the function of AfMac1, a transcriptional activator of the copper and iron regulons of Aspergillus fumigatus, on the interaction between iron and copper. In addition to the copper-specific AfMac1 binding motif 5′-TGTGCTCA-3′ found in the promoter region of ctrC , the iron-specific AfMac1 binding motif 5′-AT(C/G)NN(A/T)T(A/C)-3′ was identified in the iron regulon but not in the copper regulon by ChIP sequence analysis. Furthermore, mutation of the A…

Source: The Biochemical JournalCategory: Biochemistry Authors: Tags: Biochem J Source Type: research

In this study we compared two different deglutinization treatments on an American India Pale Ale, brewed on a craft beer pilot plant: an enzymatic process based on Aspergillus niger prolyl endopeptidase and a precipitation process by silica gel. The gluten amount in all stages of brewing, and the effects of treatments on standard quality attributes, chemical composition and sensory profile were evaluated. Both treatments were able to reduce gluten level below 20 ppm, showing a different behavior. Only slight differences were observed in the chemico-physical characteristics of treated and untreated beers, whereas sensory …

This study aimed to explore the potential of Araucaria forest fungi to produce xylanases, using passion fruit peel as the substrate. About 65 fungal lineages were isolated from Araucaria forest soil and screened for xylanase enzyme production. Among these, a fungal strain, identified as Aspergillus flavus, showed high potential for xylanase production by using passion fruit peel as the sole substrate. Process optimization resulted in a 7.89-fold increase in enzyme activity. The xylanases were stable at 55–60 °C, over a broad pH range; these are characteristics desired for pulp biobleaching. Therefore, the po…

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